Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.101 | 0.6468 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0657 | 0.4033 | 0.4309 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1429 | 0.9358 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1429 | 0.9358 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0512 | 0.3028 | 0.4682 |
Toxoplasma gondii | hypothetical protein | 0.0657 | 0.4033 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1429 | 0.9358 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1184 | 0.7665 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1429 | 0.9358 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0657 | 0.4033 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0657 | 0.4033 | 0.4309 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.0073 | 0 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.1429 | 0.9358 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0657 | 0.4033 | 0.4309 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1522 | 1 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1429 | 0.9358 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1429 | 0.9358 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1429 | 0.9358 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1429 | 0.9358 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1522 | 1 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0672 | 0.4132 | 0.6389 |
Schistosoma mansoni | carbonic anhydrase | 0.1184 | 0.7665 | 0.682 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1184 | 0.7665 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1429 | 0.9358 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0073 | 0 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.1429 | 0.9358 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1429 | 0.9358 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1272 | 0.8272 | 0.796 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.