Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.2727 | 1 | 1 |
Echinococcus multilocularis | Cyclin dependent kinase 2 associated protein | 0.0466 | 0.1659 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0092 | 0.0082 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0162 | 0.0152 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2727 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0092 | 0.0082 |
Schistosoma mansoni | deleted in oral cancer 1/cdk2-associated protein-like | 0.0466 | 0.1659 | 0.165 |
Onchocerca volvulus | Diphthamide biosynthesis protein 7 homolog | 0.0466 | 0.1659 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0695 | 0.0685 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0011 | 0.0064 |
Echinococcus granulosus | geminin | 0.0205 | 0.0695 | 0.4192 |
Echinococcus granulosus | Cyclin dependent kinase 2 associated protein | 0.0466 | 0.1659 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0011 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0092 | 0.0082 |
Echinococcus multilocularis | geminin | 0.0205 | 0.0695 | 0.4155 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0011 | 0.0064 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0162 | 0.0152 |
Brugia malayi | hypothetical protein | 0.1524 | 0.5562 | 0.5558 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0162 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0466 | 0.1659 | 0.165 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0162 | 0.0152 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0695 | 0.0685 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.3078 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 25.9185 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.