Detailed information for compound 833302

Basic information

Technical information
  • TDR Targets ID: 833302
  • Name: 2-(4H-chromeno[3,4-d]pyrazol-1-yl)-N-(2-fluor ophenyl)-N-propylacetamide
  • MW: 365.401 | Formula: C21H20FN3O2
  • H donors: 0 H acceptors: 2 LogP: 3.62 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(c1ccccc1F)C(=O)Cn1ncc2c1c1ccccc1OC2
  • InChi: 1S/C21H20FN3O2/c1-2-11-24(18-9-5-4-8-17(18)22)20(26)13-25-21-15(12-23-25)14-27-19-10-6-3-7-16(19)21/h3-10,12H,2,11,13-14H2,1H3
  • InChiKey: XNZXDBVFUZEZQO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4H-chromeno[3,4-d]pyrazol-1-yl)-N-(2-fluorophenyl)-N-propyl-acetamide
  • 2-(4H-chromeno[3,4-d]pyrazol-1-yl)-N-(2-fluorophenyl)-N-propyl-ethanamide
  • ChemDiv2_007249
  • IDI1_005964

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable reductase 0.0109 0.0087 0.6393
Schistosoma mansoni calcium-activated potassium channel 0.1633 0.6214 0.6214
Onchocerca volvulus 0.0088 0 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0088 0 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0088 0 0.5
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.0136 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0088 0 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0088 0 0.5
Onchocerca volvulus 0.0088 0 0.5
Loa Loa (eye worm) hypothetical protein 0.2574 1 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0088 0 0.5
Plasmodium vivax potassium channel, putative 0.0088 0 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0088 0 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0088 0 0.5
Toxoplasma gondii ion channel protein 0.0088 0 0.5
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0088 0 0.5
Onchocerca volvulus 0.0088 0 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0088 0 0.5
Onchocerca volvulus 0.0088 0 0.5
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.0136 1
Leishmania major ion transport protein-like protein 0.0088 0 0.5
Trypanosoma cruzi ion transport protein, putative 0.0088 0 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0088 0 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0088 0 0.5
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0088 0 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0088 0 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0088 0 0.5
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0087 0.6393
Loa Loa (eye worm) hypothetical protein 0.073 0.2585 0.2585
Leishmania major hypothetical protein, conserved 0.0088 0 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0088 0 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0088 0 0.5
Mycobacterium ulcerans transmembrane cation transporter 0.0088 0 0.5
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0088 0 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0088 0 0.5
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0088 0 0.5
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0088 0 0.5
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0088 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0902 0.3276 0.3276
Schistosoma mansoni calcium-activated potassium channel 0.2574 1 1
Toxoplasma gondii ion channel protein 0.0088 0 0.5
Echinococcus multilocularis small conductance calcium activated potassium 0.2574 1 1
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0088 0 0.5
Onchocerca volvulus 0.0088 0 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0088 0 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0088 0 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0088 0 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0088 0 0.5
Schistosoma mansoni hypothetical protein 0.2574 1 1
Plasmodium falciparum potassium channel 0.0088 0 0.5
Onchocerca volvulus 0.0088 0 0.5
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.0136 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.0136 1
Leishmania major hypothetical protein, conserved 0.0088 0 0.5
Plasmodium falciparum potassium channel 0.0088 0 0.5
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0087 0.6393
Leishmania major potassium channel subunit-like protein 0.0088 0 0.5
Onchocerca volvulus 0.0088 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0853 0.308 0.308
Brugia malayi hypothetical protein 0.0088 0 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0088 0 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0088 0 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0088 0 0.5
Trypanosoma cruzi ion transport protein, putative 0.0088 0 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0087 0.6393
Giardia lamblia Hypothetical protein 0.0088 0 0.5
Brugia malayi hypothetical protein 0.0088 0 0.5
Leishmania major calcium/potassium channel (CAKC), putative 0.0088 0 0.5
Trypanosoma brucei calcium-activated potassium channel, putative 0.0088 0 0.5
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0087 0.6393
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0087 0.6393
Mycobacterium ulcerans ion transport protein 0.0088 0 0.5
Plasmodium vivax potassium channel, putative 0.0088 0 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0088 0 0.5
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0822 0.2955 0.2955
Onchocerca volvulus 0.0088 0 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.