Detailed information for compound 833681

Basic information

Technical information
  • TDR Targets ID: 833681
  • Name: 5-butylamino-2-[2-(4-ethoxyphenyl)ethenyl]-1, 3-oxazole-4-carbonitrile
  • MW: 311.378 | Formula: C18H21N3O2
  • H donors: 1 H acceptors: 2 LogP: 5.15 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCNc1oc(nc1C#N)C=Cc1ccc(cc1)OCC
  • InChi: 1S/C18H21N3O2/c1-3-5-12-20-18-16(13-19)21-17(23-18)11-8-14-6-9-15(10-7-14)22-4-2/h6-11,20H,3-5,12H2,1-2H3/b11-8+
  • InChiKey: LKQFGEGVSLEIGW-DHZHZOJOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-butylamino-2-[(E)-2-(4-ethoxyphenyl)ethenyl]-1,3-oxazole-4-carbonitrile
  • 5-butylamino-2-[2-(4-ethoxyphenyl)vinyl]oxazole-4-carbonitrile
  • 5-butylamino-2-[(E)-2-(4-ethoxyphenyl)vinyl]oxazole-4-carbonitrile
  • 5-butylamino-2-[2-(4-ethoxyphenyl)vinyl]-4-oxazolecarbonitrile
  • 5-butylamino-2-[(E)-2-(4-ethoxyphenyl)vinyl]-4-oxazolecarbonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0525 0.146 0.1479
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.244 0.7284 0.7469
Loa Loa (eye worm) hypothetical protein 0.0294 0.0759 0.0769
Trypanosoma cruzi hypothetical protein, conserved 0.072 0.2053 0.2105
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.114 0.333 0.3415
Schistosoma mansoni histone deacetylase 4 5 0.0199 0.0467 0.0479
Echinococcus multilocularis histone deacetylase 6 0.0199 0.0467 0.0479
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.072 0.2053 0.2014
Trypanosoma cruzi histone deacetylase, putative 0.0199 0.0467 0.0479
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0951 0.2757 0.2827
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0801 0.23 0.23
Trichomonas vaginalis histone deacetylase, putative 0.055 0.1537 0.1537
Leishmania major cAMP-specific phosphodiesterase, putative 0.072 0.2053 0.2105
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.1166 0.3408 1
Schistosoma mansoni histone deacetylase 0.055 0.1537 0.1576
Leishmania major histone deacetylase, putative 0.0199 0.0467 0.0479
Trypanosoma cruzi histone deacetylase, putative 0.0167 0.037 0.038
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.114 0.333 0.3415
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.072 0.2053 0.2053
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.072 0.2053 0.2339
Leishmania major histone deacetylase, putative 0.055 0.1537 0.1576
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.0572 0.1603 0.1643
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.072 0.2053 0.2053
Loa Loa (eye worm) hypothetical protein 0.0453 0.1241 0.1257
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.3251 0.9753 0.9753
Trichomonas vaginalis histone deacetylase, putative 0.055 0.1537 0.1537
Trichomonas vaginalis conserved hypothetical protein 0.072 0.2053 0.2053
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.2257 0.6728 0.6815
Trichomonas vaginalis histone deacetylase, putative 0.055 0.1537 0.1537
Loa Loa (eye worm) hypothetical protein 0.0106 0.0186 0.0188
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.1166 0.3408 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.2167 0.6455 0.6455
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1804 0.5351 0.5351
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0081 0.0111 0.0114
Plasmodium vivax histone deacetylase 1, putative 0.055 0.1537 0.394
Schistosoma mansoni retinal rod rhodopsin-sensitive cgmp 3'5'-cyclic phosphodiesterase 0.0525 0.146 0.1497
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.3251 0.9753 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.3251 0.9753 0.9753
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0951 0.2757 0.2827
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.3251 0.9753 0.9753
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0951 0.2757 0.8501
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.072 0.2053 0.2053
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.3251 0.9753 0.9753
Loa Loa (eye worm) hypothetical protein 0.0294 0.0759 0.0769
Echinococcus multilocularis histone deacetylase 1 0.055 0.1537 0.1576
Entamoeba histolytica histone deacetylase, putative 0.055 0.1537 0.5
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.2167 0.6455 0.6455
Loa Loa (eye worm) hypothetical protein 0.0167 0.037 0.0375
Plasmodium falciparum cGMP-specific phosphodiesterase 0.072 0.2053 0.5887
Loa Loa (eye worm) histone deacetylase 1 0.055 0.1537 0.1557
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.055 0.1537 0.1537
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.072 0.2053 0.2014
Leishmania major hypothetical protein, conserved 0.072 0.2053 0.2105
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.3251 0.9753 0.9753
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.072 0.2053 0.2053
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.3251 0.9753 0.9753
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.072 0.2053 0.208
Schistosoma mansoni histone deacetylase 1 2 3 0.0167 0.037 0.038
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.072 0.2053 0.2105
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.072 0.2053 0.2053
Trichomonas vaginalis histone deacetylase, putative 0.055 0.1537 0.1537
Trypanosoma cruzi histone deacetylase 1, putative 0.055 0.1537 0.1576
Toxoplasma gondii hypothetical protein 0.2531 0.7563 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.055 0.1537 0.1537
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.3251 0.9753 0.9753
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.072 0.2053 0.2339
Trypanosoma brucei histone deacetylase 1 0.055 0.1537 0.1479
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.072 0.2053 0.2053
Echinococcus granulosus histone deacetylase 3 0.055 0.1537 0.1576
Trypanosoma cruzi histone deacetylase, putative 0.0199 0.0467 0.0479
Brugia malayi hypothetical protein 0.0525 0.146 0.1479
Loa Loa (eye worm) hypothetical protein 0.1014 0.2949 0.2987
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.2257 0.6728 0.6899
Echinococcus granulosus histone deacetylase 7 0.0199 0.0467 0.0479
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.0572 0.1603 0.1623
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.0572 0.1603 0.1643
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.3251 0.9753 0.9753
Brugia malayi histone deacetylase 1 (HD1) 0.055 0.1537 0.1557
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.3251 0.9753 0.9753
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.072 0.2053 0.2339
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.051 0.1413 0.1431
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.3251 0.9753 1
Schistosoma mansoni amine GPCR 0.0179 0.0408 0.0418
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.2257 0.6728 0.6899
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.072 0.2053 0.2339
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.3251 0.9753 1
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.1084 0.3161 0.9249
Trypanosoma brucei UNC119 0.0106 0.0186 0.0078
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.1913 0.568 0.5825
Brugia malayi histone deacetylase 3 (HD3) 0.055 0.1537 0.1557
Plasmodium vivax hypothetical protein, conserved 0.1084 0.3161 0.9427
Trichomonas vaginalis histone deacetylase, putative 0.055 0.1537 0.1537
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0801 0.23 0.23
Loa Loa (eye worm) hypothetical protein 0.1537 0.4538 0.4597
Echinococcus granulosus histone deacetylase 0.0199 0.0467 0.0479
Trypanosoma cruzi hypothetical protein, conserved 0.072 0.2053 0.2105
Giardia lamblia Hypothetical protein 0.072 0.2053 0.5465
Plasmodium falciparum phosphodiesterase gamma, putative 0.072 0.2053 0.5887
Loa Loa (eye worm) hypothetical protein 0.055 0.1537 0.1557
Echinococcus granulosus histone deacetylase 6 0.0206 0.0489 0.0501
Plasmodium vivax phosphodiesterase gamma, putative 0.072 0.2053 0.5685
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.051 0.1413 0.1431
Trypanosoma brucei histone deacetylase, putative 0.0199 0.0467 0.037
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.072 0.2053 0.2339
Loa Loa (eye worm) hypothetical protein 0.1229 0.3603 0.3649
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.114 0.333 1
Echinococcus granulosus histone deacetylase 6 0.0199 0.0467 0.0479
Echinococcus multilocularis geminin 0.0176 0.0397 0.0407
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.072 0.2053 0.5685
Brugia malayi indoleamine 2,3-dioxygenase 0.0572 0.1603 0.1623
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.114 0.333 0.3415
Toxoplasma gondii histone deacetylase HDAC3 0.055 0.1537 0.1621
Trichomonas vaginalis conserved hypothetical protein 0.2531 0.7563 0.7563
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.072 0.2053 0.5887
Toxoplasma gondii hypothetical protein 0.1084 0.3161 0.388
Giardia lamblia hypothetical protein 0.072 0.2053 0.5465
Echinococcus granulosus histone deacetylase 6 0.0199 0.0467 0.0479
Brugia malayi Histone deacetylase family protein 0.0199 0.0467 0.0473
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.3251 0.9753 0.9753
Trypanosoma cruzi UNC119 0.0106 0.0186 0.019
Trypanosoma cruzi hypothetical protein, conserved 0.072 0.2053 0.2105
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.3333 1 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.244 0.7284 0.7469
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.3251 0.9753 0.9753
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1229 0.3603 0.3694
Echinococcus multilocularis histone deacetylase 0.0199 0.0467 0.0479
Leishmania major histone deacetylase, putative 0.0199 0.0467 0.0479
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.1229 0.3603 0.3694
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.072 0.2053 0.2339
Echinococcus multilocularis histone deacetylase 3 0.055 0.1537 0.1576
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.072 0.2053 0.2339
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.072 0.2053 0.2105
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.2226 0.6635 0.6803
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.1229 0.3603 0.3694
Schistosoma mansoni hypothetical protein 0.0176 0.0397 0.0407
Trypanosoma brucei cAMP-specific phosphodiesterase 0.3251 0.9753 1
Echinococcus granulosus histone deacetylase 8 0.0167 0.037 0.038
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.072 0.2053 0.2339
Trichomonas vaginalis conserved hypothetical protein 0.072 0.2053 0.2053
Toxoplasma gondii histone deacetylase HDAC1 0.0199 0.0467 0.0135
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.2226 0.6635 0.6721
Schistosoma mansoni histone deacetylase 0.055 0.1537 0.1576
Loa Loa (eye worm) histone deacetylase 7A 0.0199 0.0467 0.0473
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.3251 0.9753 0.9753
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.051 0.1413 0.1449
Schistosoma mansoni histone deacetylase 4 5 0.0199 0.0467 0.0479
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.3251 0.9753 0.9753
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.072 0.2053 0.2053
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.114 0.333 0.4115
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.1014 0.2949 0.2987
Trypanosoma cruzi hypothetical protein, conserved 0.072 0.2053 0.2105
Trichomonas vaginalis conserved hypothetical protein 0.2531 0.7563 0.7563
Leishmania major hypothetical protein, conserved 0.0106 0.0186 0.019
Giardia lamblia Histone deacetylase 0.055 0.1537 0.3954
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.072 0.2053 0.2105
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1229 0.3603 0.3694
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.072 0.2053 0.2339
Trypanosoma brucei cAMP-specific phosphodiesterase 0.3251 0.9753 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.1014 0.2949 0.3023
Echinococcus granulosus histone deacetylase 1 0.055 0.1537 0.1576
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.3251 0.9753 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.072 0.2053 0.2339
Plasmodium falciparum phosphodiesterase delta, putative 0.072 0.2053 0.5887
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.114 0.333 0.3339
Trypanosoma cruzi histone deacetylase, putative 0.0167 0.037 0.038
Toxoplasma gondii GAF domain-containing protein 0.1084 0.3161 0.388
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.1014 0.2949 0.2987
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.072 0.2053 0.2105
Schistosoma mansoni histone deacetylase hda2 0.0206 0.0489 0.0501
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.072 0.2053 0.2014
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.114 0.333 0.4115
Schistosoma mansoni hypothetical protein 0.0176 0.0397 0.0407
Leishmania major protein kinase, putative 0.005 0.0015 0.0016
Plasmodium falciparum histone deacetylase 1 0.055 0.1537 0.397
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.072 0.2053 0.2105
Loa Loa (eye worm) hypothetical protein 0.0294 0.0759 0.0769
Echinococcus multilocularis histone deacetylase 6 0.0199 0.0467 0.0479
Loa Loa (eye worm) hypothetical protein 0.2226 0.6635 0.6721
Trichomonas vaginalis conserved hypothetical protein 0.1084 0.3161 0.3161
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.114 0.333 0.3415
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.3251 0.9753 0.9753
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.072 0.2053 0.2105
Plasmodium falciparum cGMP-specific phosphodiesterase 0.072 0.2053 0.5887
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.072 0.2053 0.2105
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.072 0.2053 0.2339
Trichomonas vaginalis retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase, putative 0.0525 0.146 0.146
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0951 0.2757 0.2827
Plasmodium vivax histone deacetylase, putative 0.0199 0.0467 0.0328
Plasmodium falciparum GAF domain-related protein, putative 0.1084 0.3161 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.055 0.1537 0.1537
Trypanosoma cruzi hypothetical protein, conserved 0.072 0.2053 0.2105
Trypanosoma brucei hypothetical protein, conserved 0.072 0.2053 0.2014
Loa Loa (eye worm) histone deacetylase 0.0199 0.0467 0.0473
Echinococcus multilocularis histone deacetylase 8 0.0167 0.037 0.038
Trypanosoma cruzi UNC119 0.0106 0.0186 0.019
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.051 0.1413 0.1449
Toxoplasma gondii histone deacetylase HDAC2 0.055 0.1537 0.1621
Trypanosoma brucei histone deacetylase 3 0.0199 0.0467 0.037
Trichomonas vaginalis histone deacetylase, putative 0.055 0.1537 0.1537
Trypanosoma brucei histone deacetylase 2 0.0167 0.037 0.0269
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0045 0 0.5
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.3251 0.9753 0.9753
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0081 0.0111 0.0114
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.114 0.333 0.3415
Schistosoma mansoni hypothetical protein 0.0572 0.1603 0.1643
Toxoplasma gondii hypothetical protein 0.1084 0.3161 0.388
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.3333 1 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.3251 0.9753 0.9753
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.3251 0.9753 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.244 0.7284 0.7378
Schistosoma mansoni hypothetical protein 0.0572 0.1603 0.1643
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.3251 0.9753 0.9753
Trypanosoma cruzi histone deacetylase, putative 0.0199 0.0467 0.0479
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.3251 0.9753 0.9753
Loa Loa (eye worm) PDE1B protein 0.244 0.7284 0.7378
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.3291 0.9872 1
Mycobacterium leprae conserved hypothetical protein 0.1084 0.3161 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.3251 0.9753 0.9753
Trypanosoma cruzi histone deacetylase 1, putative 0.055 0.1537 0.1576
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.072 0.2053 0.2339
Onchocerca volvulus Histone deacetylase 10 homolog 0.0167 0.037 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0722 0.2061 0.235
Brugia malayi histone deacetylase 11 0.0167 0.037 0.0375
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.3251 0.9753 0.9753
Echinococcus multilocularis histone deacetylase 6 0.0206 0.0489 0.0501
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.3251 0.9753 0.9753
Brugia malayi hypothetical protein 0.0106 0.0186 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.3333 1 1
Loa Loa (eye worm) hypothetical protein 0.3291 0.9872 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1804 0.5351 0.5351
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.3251 0.9753 0.9753
Leishmania major hypothetical protein, conserved 0.0081 0.0111 0.0114
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.072 0.2053 0.2053
Loa Loa (eye worm) histone deacetylase 11 0.0167 0.037 0.0375
Echinococcus multilocularis histone deacetylase 7 0.0199 0.0467 0.0479
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0951 0.2757 0.3318
Leishmania major histone deacetylase, putative 0.055 0.1537 0.1576
Brugia malayi Histone deacetylase 1 0.055 0.1537 0.1557
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.3251 0.9753 0.9753
Trypanosoma brucei histone deacetylase 4 0.0199 0.0467 0.037
Loa Loa (eye worm) hypothetical protein 0.2571 0.7682 0.7782
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.1229 0.3603 1
Leishmania major hypothetical protein, conserved 0.072 0.2053 0.2105
Plasmodium vivax histone deacetylase 2, putative 0.0199 0.0467 0.0328
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.3251 0.9753 0.9753
Trichomonas vaginalis conserved hypothetical protein 0.2531 0.7563 0.7563
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.1913 0.568 0.5825
Loa Loa (eye worm) histone deacetylase 3 0.055 0.1537 0.1557
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.244 0.7284 0.7469
Brugia malayi Histone deacetylase family protein 0.0199 0.0467 0.0473
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.3251 0.9753 1
Trypanosoma cruzi hypothetical protein, conserved 0.072 0.2053 0.2105
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.1229 0.3603 0.3694
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1232 0.361 0.4505
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.1804 0.5351 0.5351
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.2167 0.6455 0.6619
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.072 0.2053 0.5685
Schistosoma mansoni histone deacetylase hda2 0.0167 0.037 0.038
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.072 0.2053 0.2339
Echinococcus granulosus geminin 0.0176 0.0397 0.0407
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.3251 0.9753 0.9753

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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