Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0444 | 0.2471 | 0.5 |
Onchocerca volvulus | 0.0275 | 0.0875 | 0.5775 | |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0316 | 0.126 | 0.0421 |
Onchocerca volvulus | 0.0316 | 0.126 | 1 | |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0337 | 0.1457 | 1 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.1244 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0337 | 0.1457 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0337 | 0.1457 | 1 |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.0275 | 0.0875 | 0.6007 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0316 | 0.126 | 0.8646 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0337 | 0.1457 | 0.0638 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0444 | 0.2471 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0444 | 0.2471 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0337 | 0.1457 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0337 | 0.1457 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0337 | 0.1457 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0337 | 0.1457 | 0.0638 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0337 | 0.1457 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0337 | 0.1457 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0444 | 0.2471 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.1244 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0316 | 0.126 | 0.0421 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0444 | 0.2471 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0444 | 0.2471 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.