Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glycogen phosphorylase | 0.0109 | 0.2576 | 0.252 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0109 | 0.2576 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0109 | 0.2576 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0109 | 0.2576 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0109 | 0.2576 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0109 | 0.2576 | 0.252 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0109 | 0.2576 | 0.252 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0109 | 0.2576 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0608 | 0.2002 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0648 | 0.0648 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.0648 | 0.0578 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0055 | 0.1242 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.3332 | 0.3871 |
Schistosoma mansoni | glycogen phosphorylase | 0.0047 | 0.1056 | 0.1056 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0074 | 0.0074 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0061 | 0.1403 | 0.1403 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0296 | 0.7153 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0608 | 0.1993 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0109 | 0.2576 | 0.252 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.1142 | 0.0358 |
Schistosoma mansoni | glycogen phosphorylase | 0.0109 | 0.2576 | 0.2576 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.0648 | 0.0578 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0109 | 0.2576 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0109 | 0.2576 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0412 | 1 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0648 | 0.0648 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0412 | 1 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0109 | 0.2576 | 0.252 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0156 | 0.372 | 1 |
Brugia malayi | carbohydrate phosphorylase | 0.0109 | 0.2576 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0156 | 0.372 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0296 | 0.7153 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0296 | 0.7153 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0296 | 0.7153 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.0109 | 0.2576 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0118 | 0.0044 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0608 | 0.0608 |
Schistosoma mansoni | glycogen phosphorylase | 0.0109 | 0.2576 | 0.2576 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0118 | 0.0044 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.014 | 0.3332 | 0.3871 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0109 | 0.2576 | 0.252 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.