Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypoxia-induced factor 1 | 0.0156 | 0.2132 | 0.2984 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.2293 | 0.3004 |
Mycobacterium ulcerans | putative regulatory protein | 0.0037 | 0 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0165 | 0.2293 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0049 | 0.021 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0436 | 0.7146 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0524 | 0.8728 | 1 |
Brugia malayi | glutathione reductase | 0.0049 | 0.021 | 0.0294 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0051 | 0.0235 | 0.0016 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0156 | 0.2132 | 0.2772 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0159 | 0.2184 | 0.9525 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.005 | 0.0222 | 0.0967 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0049 | 0.021 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0595 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.5555 | 0.7707 |
Onchocerca volvulus | 0.0524 | 0.8728 | 0.8728 | |
Brugia malayi | Pre-SET motif family protein | 0.0436 | 0.7146 | 1 |
Brugia malayi | SET domain containing protein | 0.0365 | 0.5874 | 0.822 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0165 | 0.2293 | 0.2435 |
Brugia malayi | Thioredoxin reductase | 0.0049 | 0.021 | 0.0294 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0165 | 0.2293 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0165 | 0.2293 | 0.2435 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.2368 | 0.3111 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0165 | 0.2293 | 0.2435 |
Brugia malayi | PAS domain containing protein | 0.0051 | 0.0235 | 0.0329 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0165 | 0.2293 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0049 | 0.021 | 0.5 |
Schistosoma mansoni | single-minded | 0.0051 | 0.0235 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.5765 | 0.8009 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0049 | 0.021 | 0.5 |
Leishmania major | trypanothione reductase | 0.0049 | 0.021 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0165 | 0.2293 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0049 | 0.021 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0165 | 0.2293 | 0.3209 |
Plasmodium vivax | SET domain protein, putative | 0.0165 | 0.2293 | 1 |
Brugia malayi | hypothetical protein | 0.0169 | 0.2368 | 0.3313 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.005 | 0.0222 | 0.0967 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.