Detailed information for compound 834431

Basic information

Technical information
  • TDR Targets ID: 834431
  • Name: 7-chloro-3-phenylsulfonyl-N-propan-2-yltriazo lo[1,5-a]quinazolin-5-amine
  • MW: 401.87 | Formula: C18H16ClN5O2S
  • H donors: 1 H acceptors: 5 LogP: 3.99 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Nc1nc2n(c3c1cc(Cl)cc3)nnc2S(=O)(=O)c1ccccc1)C
  • InChi: 1S/C18H16ClN5O2S/c1-11(2)20-16-14-10-12(19)8-9-15(14)24-17(21-16)18(22-23-24)27(25,26)13-6-4-3-5-7-13/h3-11H,1-2H3,(H,20,21)
  • InChiKey: ZYCQYPHOTCDLQF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-chloro-N-isopropyl-3-phenylsulfonyl-triazolo[1,5-a]quinazolin-5-amine
  • 7-chloro-N-isopropyl-3-phenylsulfonyl-5-triazolo[1,5-a]quinazolinamine
  • (7-chloro-3-phenylsulfonyl-triazolo[1,5-a]quinazolin-5-yl)-isopropyl-amine
  • 7-chloro-3-phenylsulfonyl-N-propan-2-yl-[1,2,3]triazolo[1,5-a]quinazolin-5-amine
  • ZINC04483738

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax DNA gyrase subunit B, putative 0.0652 0.8578 1
Trypanosoma brucei C-8 sterol isomerase, putative 0.0753 1 1
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0423 0.0423
Chlamydia trachomatis DNA gyrase subunit B 0.0652 0.8578 1
Loa Loa (eye worm) hypothetical protein 0.0753 1 1
Brugia malayi RNA binding protein 0.0076 0.0423 0.0423
Trypanosoma cruzi DNA topoisomerase II, putative 0.0106 0.0838 0.0838
Plasmodium falciparum DNA topoisomerase 2 0.0152 0.1499 0.1747
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0377 0.4679 0.4679
Loa Loa (eye worm) hypothetical protein 0.0385 0.4788 0.4788
Echinococcus granulosus tar DNA binding protein 0.0076 0.0423 0.2824
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0377 0.4679 0.4679
Plasmodium falciparum DNA gyrase subunit B 0.0652 0.8578 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.0423 0.0423
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1382 0.1382
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0225 0.252 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0423 0.2824
Trichomonas vaginalis DNA topoisomerase II, putative 0.0152 0.1499 1
Mycobacterium ulcerans DNA gyrase subunit B 0.0652 0.8578 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1382 0.1382
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0652 0.8578 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0838 0.0838
Loa Loa (eye worm) hypothetical protein 0.0106 0.0838 0.0838
Entamoeba histolytica DNA topoisomerase II, putative 0.0152 0.1499 1
Schistosoma mansoni DNA topoisomerase II 0.0152 0.1499 1
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0106 0.0838 0.0838
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0152 0.1499 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0106 0.0838 0.0838
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0753 1 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0423 0.2824
Loa Loa (eye worm) TOPoisomerase family member 0.0152 0.1499 0.1499
Brugia malayi MH2 domain containing protein 0.0144 0.1382 0.1382
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0152 0.1499 0.1499
Giardia lamblia DNA topoisomerase II 0.0132 0.1209 1
Leishmania major C-8 sterol isomerase-like protein 0.0753 1 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0423 0.2824
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0423 0.2824
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0152 0.1499 0.1499
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0106 0.0838 0.0838
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0152 0.1499 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0423 0.0423
Trypanosoma brucei DNA topoisomerase ii 0.0377 0.4679 0.4679
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0152 0.1499 1
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0652 0.8578 1
Leishmania major DNA topoisomerase ii 0.0106 0.0838 0.0838
Brugia malayi TAR-binding protein 0.0076 0.0423 0.0423
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0377 0.4679 1
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0152 0.1499 1
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0152 0.1499 1
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0652 0.8578 1
Plasmodium vivax DNA topoisomerase II, putative 0.0152 0.1499 0.1747
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0423 0.2824
Leishmania major mitochondrial DNA topoisomerase II 0.0377 0.4679 0.4679
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0423 0.0423
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0423 0.2824
Toxoplasma gondii DNA topoisomerase 2, putative 0.0152 0.1499 0.3202
Chlamydia trachomatis DNA gyrase subunit B 0.0428 0.5397 0.6292
Brugia malayi Probable DNA topoisomerase II 0.0152 0.1499 0.1499

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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