Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | S-adenosylmethionine decarboxylase/ornithine decarboxylase | 0.0124 | 0.3742 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0108 | 0.2933 | 0.7846 |
Leishmania major | ornithine decarboxylase, putative | 0.0124 | 0.3742 | 1 |
Entamoeba histolytica | ornithine decarboxylase, putative | 0.0124 | 0.3742 | 0.5 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0095 | 0.2332 | 0.6233 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0108 | 0.2933 | 0.7344 |
Trypanosoma cruzi | p450 reductase, putative | 0.0108 | 0.2933 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0122 | 0.3664 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0122 | 0.3664 | 1 |
Trichomonas vaginalis | diaminopimelate decarboxylase, putative | 0.0124 | 0.3742 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0054 | 0.0311 | 0.0118 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0108 | 0.2933 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0108 | 0.2933 | 0.2224 |
Mycobacterium leprae | PROBABLE DIAMINOPIMELATE DECARBOXYLASE LYSA (DAP DECARBOXYLASE) | 0.0048 | 0 | 0.5 |
Giardia lamblia | Ornithine decarboxylase | 0.0124 | 0.3742 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0086 | 0.1854 | 0.4666 |
Mycobacterium tuberculosis | Diaminopimelate decarboxylase LysA (DAP decarboxylase) | 0.0124 | 0.3742 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0108 | 0.2933 | 0.5 |
Onchocerca volvulus | 0.0124 | 0.3742 | 0.5 | |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0108 | 0.2933 | 0.7344 |
Brugia malayi | Pyridoxal-dependent decarboxylase, pyridoxal binding domain containing protein | 0.0124 | 0.3742 | 0.3114 |
Trichomonas vaginalis | ornithine decarboxylase, putative | 0.0124 | 0.3742 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0251 | 1 | 1 |
Toxoplasma gondii | diaminopimelate decarboxylase | 0.0124 | 0.3742 | 1 |
Plasmodium vivax | S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative | 0.0124 | 0.3742 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.2933 | 0.2224 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0108 | 0.2933 | 0.7344 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0108 | 0.2933 | 0.7839 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0108 | 0.2933 | 0.4262 |
Brugia malayi | flavodoxin family protein | 0.0108 | 0.2933 | 0.2224 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0108 | 0.2933 | 0.2224 |
Trichomonas vaginalis | pyridoxal-dependent decarboxylase, putative | 0.0124 | 0.3742 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0066 | 0.0912 | 0.1889 |
Chlamydia trachomatis | sulfite reductase | 0.0066 | 0.0912 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0108 | 0.2933 | 0.4262 |
Loa Loa (eye worm) | pyridoxal-dependent decarboxylase | 0.0124 | 0.3742 | 0.3114 |
Trichomonas vaginalis | ornithine decarboxylase, putative | 0.0124 | 0.3742 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0108 | 0.2933 | 0.5 |
Trypanosoma brucei | ornithine decarboxylase | 0.0124 | 0.3742 | 1 |
Mycobacterium ulcerans | diaminopimelate decarboxylase LysA | 0.0124 | 0.3742 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0122 | 0.3664 | 1 |
Leishmania major | p450 reductase, putative | 0.0108 | 0.2933 | 0.4262 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0108 | 0.2933 | 0.7344 |
Trichomonas vaginalis | diaminopimelate decarboxylase, putative | 0.0124 | 0.3742 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0251 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.