Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alpha-glucosidase | 0.1062 | 0.67 | 1 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.1458 | 1 | 1 |
Onchocerca volvulus | 0.0876 | 0.5157 | 0.5 | |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0882 | 0.5204 | 0.7242 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.112 | 0.7186 | 1 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.1458 | 1 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.1062 | 0.67 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0387 | 0.1087 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.112 | 0.7186 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0387 | 0.1087 | 1 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0882 | 0.5204 | 0.7242 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 10.3 mg kg-1 | Sedative activity in mice | ChEMBL. | 2876098 |
ED50 (functional) | = 10.3 mg kg-1 | Sedative activity in mice | ChEMBL. | 2876098 |
ED50 (functional) | = 39 mg kg-1 | Anticholinergic activity in mice. | ChEMBL. | 2876098 |
ED50 (functional) | = 39 mg kg-1 | Anticholinergic activity in mice. | ChEMBL. | 2876098 |
Relative activity (functional) | = 0.36 | Anticholinergic activity relative with respect to clozapine. | ChEMBL. | 2876098 |
Relative activity (functional) | = 0.46 | Sedative activity relative with respect to clozapine. | ChEMBL. | 2876098 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.