Detailed information for compound 835610

Basic information

Technical information
  • TDR Targets ID: 835610
  • Name: N-[(4-methoxyphenyl)methyl]-2-pyridin-2-ylsul fanylacetamide
  • MW: 288.365 | Formula: C15H16N2O2S
  • H donors: 1 H acceptors: 2 LogP: 2.51 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CNC(=O)CSc1ccccn1
  • InChi: 1S/C15H16N2O2S/c1-19-13-7-5-12(6-8-13)10-17-14(18)11-20-15-4-2-3-9-16-15/h2-9H,10-11H2,1H3,(H,17,18)
  • InChiKey: HJRCQBIRMVVPRQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(4-methoxyphenyl)methyl]-2-(2-pyridylsulfanyl)acetamide
  • N-[(4-methoxyphenyl)methyl]-2-(2-pyridylthio)acetamide
  • N-(4-methoxybenzyl)-2-(2-pyridylthio)acetamide
  • N-[(4-methoxyphenyl)methyl]-2-pyridin-2-ylsulfanyl-ethanamide
  • ZINC00181667
  • STOCK2S-29972
  • BAS 05986587
  • BIM-0021197.P001
  • EU-0071078
  • CBMicro_021371
  • N-(4-Methoxy-benzyl)-2-(pyridin-2-ylsulfanyl)-acetamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase Src42A 0.016 0.4675 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.016 0.4675 1
Echinococcus multilocularis SH2 motif 0.0094 0.0106 0.0227
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.016 0.4675 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.016 0.4675 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.016 0.4675 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.016 0.4675 1
Schistosoma mansoni hypothetical protein 0.0236 1 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0106 0.0106
Brugia malayi SRC-1 0.016 0.4675 0.4618
Echinococcus multilocularis c src tyrosine kinase 0.016 0.4675 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.016 0.4675 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0106 0.0106
Echinococcus granulosus tyrosine protein kinase Lyn 0.016 0.4675 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.016 0.4675 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.016 0.4675 1
Loa Loa (eye worm) hypothetical protein 0.016 0.4675 0.4675
Loa Loa (eye worm) hypothetical protein 0.0094 0.0106 0.0106
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0094 0.0106 0.0227
Echinococcus granulosus tyrosine protein kinase Src42A 0.0094 0.0106 0.0227
Loa Loa (eye worm) hypothetical protein 0.0094 0.0106 0.0106
Schistosoma mansoni tyrosine kinase 0.016 0.4675 0.4618
Loa Loa (eye worm) STAT protein 0.0094 0.0106 0.0106
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.016 0.4675 1
Schistosoma mansoni tyrosine kinase 0.016 0.4675 0.4618
Echinococcus granulosus tyrosine protein kinase shark 0.016 0.4675 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0094 0.0106 0.0106
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0094 0.0106 0.0227
Echinococcus granulosus tyrosine protein kinase Srms 0.016 0.4675 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.016 0.4675 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0094 0.0106 0.0106
Echinococcus multilocularis SHC transforming protein 3 0.0094 0.0106 0.0227
Onchocerca volvulus 0.016 0.4675 0.4618
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0094 0.0106 0.0227
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0109 0.1195 0.2556
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0094 0.0106 0.0227
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.016 0.4675 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.016 0.4675 1
Brugia malayi Protein kinase domain containing protein 0.016 0.4675 0.4618
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0109 0.1195 0.2556
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0109 0.1195 0.1101
Onchocerca volvulus 0.016 0.4675 0.4618
Echinococcus multilocularis tyrosine protein kinase Fgr 0.016 0.4675 1
Loa Loa (eye worm) TK/FER protein kinase 0.016 0.4675 0.4675
Schistosoma mansoni tyrosine kinase 0.016 0.4675 0.4618
Echinococcus multilocularis SH2 motif 0.0094 0.0106 0.0227
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0109 0.1195 0.2556
Echinococcus multilocularis tyrosine protein kinase Fyn 0.016 0.4675 1
Schistosoma mansoni tyrosine kinase 0.016 0.4675 0.4618
Echinococcus granulosus SH2 domain containing protein 7 0.0094 0.0106 0.0227
Echinococcus multilocularis tyrosine protein kinase ABL1 0.016 0.4675 1
Onchocerca volvulus 0.016 0.4675 0.4618
Entamoeba histolytica SH2-protein kinase domain containing protein 0.016 0.4675 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.1195 0.1195
Onchocerca volvulus 0.0236 1 1
Brugia malayi Protein kinase domain containing protein 0.016 0.4675 0.4618
Loa Loa (eye worm) TK protein kinase 0.016 0.4675 0.4675
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0236 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.016 0.4675 0.4675
Echinococcus multilocularis signal transduction protein lnk realted 0.0094 0.0106 0.0227
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0094 0.0106 0.0227
Echinococcus multilocularis tensin 0.0094 0.0106 0.0227
Loa Loa (eye worm) TK/FER protein kinase 0.016 0.4675 0.4675
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0094 0.0106 0.0106
Echinococcus granulosus hypothetical protein 0.0094 0.0106 0.0227
Echinococcus granulosus tyrosine protein kinase Blk 0.016 0.4675 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0106 0.0106
Loa Loa (eye worm) TK/FER protein kinase 0.016 0.4675 0.4675
Loa Loa (eye worm) hypothetical protein 0.0094 0.0106 0.0106
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0094 0.0106 0.0106
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.016 0.4675 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0109 0.1195 0.2556
Loa Loa (eye worm) hypothetical protein 0.0094 0.0106 0.0106
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0094 0.0106 0.0227
Echinococcus granulosus c src tyrosine kinase 0.016 0.4675 1
Echinococcus granulosus SH2 motif 0.0094 0.0106 0.0227
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0109 0.1195 0.2556
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0094 0.0106 0.0106
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.016 0.4675 1
Schistosoma mansoni tyrosine kinase 0.016 0.4675 0.4618
Echinococcus multilocularis tyrosine protein kinase Src42A 0.016 0.4675 1
Loa Loa (eye worm) TK/FER protein kinase 0.016 0.4675 0.4675
Echinococcus granulosus signal transduction protein lnk realted 0.0094 0.0106 0.0227
Echinococcus granulosus tyrosine kinase 0.016 0.4675 1
Echinococcus granulosus SHC transforming protein 3 0.0094 0.0106 0.0227
Echinococcus multilocularis 0.0094 0.0106 0.0227
Echinococcus granulosus NCK adaptor protein 0.0094 0.0106 0.0227
Echinococcus granulosus expressed conserved protein 0.0094 0.0106 0.0227
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0094 0.0106 0.0227
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0094 0.0106 0.0106
Loa Loa (eye worm) TK/FER protein kinase 0.016 0.4675 0.4675
Echinococcus multilocularis tensin 0.0094 0.0106 0.0227
Loa Loa (eye worm) hypothetical protein 0.0094 0.0106 0.0106
Onchocerca volvulus 0.016 0.4675 0.4618
Loa Loa (eye worm) hypothetical protein 0.0094 0.0106 0.0106
Echinococcus granulosus SH2 motif 0.0094 0.0106 0.0227
Echinococcus granulosus suppressor of cytokine signaling 7 0.0094 0.0106 0.0227
Echinococcus granulosus tyrosine protein kinase Src64B 0.016 0.4675 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0094 0.0106 0.0106
Loa Loa (eye worm) TK/FER protein kinase 0.016 0.4675 0.4675
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0109 0.1195 0.2556
Brugia malayi hypothetical protein 0.016 0.4675 0.4618
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0109 0.1195 0.1101
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0094 0.0106 0.0227
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0094 0.0106 0.0227
Loa Loa (eye worm) TK/ABL protein kinase 0.016 0.4675 0.4675
Echinococcus multilocularis tyrosine protein kinase Fyn 0.016 0.4675 1
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0109 0.1195 0.1101
Echinococcus multilocularis NCK adaptor protein 0.0094 0.0106 0.0227
Echinococcus multilocularis tyrosine protein kinase Abl 0.016 0.4675 1
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0094 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0109 0.1195 0.1195
Loa Loa (eye worm) TK/FER protein kinase 0.016 0.4675 0.4675
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0109 0.1195 0.2556
Echinococcus granulosus tyrosine protein kinase Btk29A 0.016 0.4675 1
Loa Loa (eye worm) SRC-1 0.016 0.4675 0.4675
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0109 0.1195 0.2556
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0109 0.1195 0.2556
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0109 0.1195 0.1101
Brugia malayi SH2 domain containing protein 0.016 0.4675 0.4618
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0094 0.0106 0.0106
Echinococcus multilocularis growth factor receptor bound protein 2 0.0094 0.0106 0.0227
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.016 0.4675 0.4618
Schistosoma mansoni tyrosine kinase 0.016 0.4675 0.4618
Loa Loa (eye worm) hypothetical protein 0.0094 0.0106 0.0106
Onchocerca volvulus 0.0109 0.1195 0.1101
Onchocerca volvulus 0.016 0.4675 0.4618
Loa Loa (eye worm) hypothetical protein 0.0094 0.0106 0.0106
Echinococcus granulosus N chimaerin 0.0094 0.0106 0.0227
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0094 0.0106 0.0227
Brugia malayi Protein kinase domain containing protein 0.016 0.4675 0.4618
Echinococcus multilocularis SH2 motif 0.0094 0.0106 0.0227
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0094 0.0106 0.0227
Brugia malayi SH2 domain containing protein 0.016 0.4675 0.4618
Brugia malayi Protein kinase domain containing protein 0.016 0.4675 0.4618
Loa Loa (eye worm) hypothetical protein 0.0094 0.0106 0.0106
Echinococcus granulosus tyrosine kinase 0.016 0.4675 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0094 0.0106 0.0227
Loa Loa (eye worm) TK/FER protein kinase 0.016 0.4675 0.4675
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0094 0.0106 0.0227
Echinococcus multilocularis tyrosine kinase 0.016 0.4675 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.016 0.4675 1
Echinococcus multilocularis N chimaerin 0.0094 0.0106 0.0227
Loa Loa (eye worm) TK/FER protein kinase 0.016 0.4675 0.4675
Onchocerca volvulus 0.0109 0.1195 0.1101
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0109 0.1195 0.1101
Echinococcus granulosus tyrosine protein kinase ABL1 0.016 0.4675 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0094 0.0106 0.0106
Onchocerca volvulus 0.016 0.4675 0.4618
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0094 0.0106 0.0227
Echinococcus granulosus suppressor of cytokine signaling 6 0.0094 0.0106 0.0227
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0109 0.1195 0.2556
Echinococcus multilocularis tyrosine protein kinase shark 0.016 0.4675 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0106 0.0106
Echinococcus multilocularis tyrosine protein kinase Src64B 0.016 0.4675 1
Brugia malayi Protein kinase domain containing protein 0.016 0.4675 0.4618
Brugia malayi Tyrosine-protein kinase abl-1 0.016 0.4675 0.4618
Echinococcus multilocularis tyrosine protein kinase Fyn 0.016 0.4675 1
Brugia malayi protein-tyrosine kinase 0.016 0.4675 0.4618
Echinococcus granulosus SH2 domain containing adapter protein F 0.0094 0.0106 0.0227
Echinococcus granulosus tensin 0.0094 0.0106 0.0227
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0094 0.0106 0.0227
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0109 0.1195 0.2556
Echinococcus multilocularis SH2 domain containing protein 7 0.0094 0.0106 0.0227
Loa Loa (eye worm) hypothetical protein 0.0109 0.1195 0.1195

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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