Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0494 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0494 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0494 | 0.3801 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0013 | 0.13 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.3801 |
Leishmania major | cytochrome p450-like protein | 0.0013 | 0.13 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0013 | 0.13 | 0.0848 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0494 | 0.3801 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0013 | 0.13 | 0.0848 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.3801 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0494 | 0.3801 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0494 | 0.3801 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.3801 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.13 | 1 |
Onchocerca volvulus | 0.001 | 0.0494 | 0.5 | |
Loa Loa (eye worm) | CYP4Cod1 | 0.0013 | 0.13 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0494 | 0.3801 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.3801 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0494 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0494 | 0.3801 |
Trypanosoma brucei | cytochrome P450, putative | 0.0013 | 0.13 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.13 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.3801 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0494 | 0.3801 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.3801 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.3801 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0013 | 0.13 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0494 | 0.3801 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0013 | 0.13 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.3801 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.