TDR Targets

Basic information

Technical information

TDR Targets ID: 837321
Name: N-(3-chloro-4-fluorophenyl)-3-[2-(3-fluorophe nyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-6-y l]propanamide
MW: 440.873 | Formula: C23H19ClF2N4O
H donors: 1 H acceptors: 3 LogP: 4.68 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc(c(c1)Cl)F)CCc1c(C)nc2n(c1C)nc(c2)c1cccc(c1)F
InChi: 1S/C23H19ClF2N4O/c1-13-18(7-9-23(31)28-17-6-8-20(26)19(24)11-17)14(2)30-22(27-13)12-21(29-30)15-4-3-5-16(25)10-15/h3-6,8,10-12H,7,9H2,1-2H3,(H,28,31)
InChiKey: ALKXWWJFOBKPLK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3-chloro-4-fluoro-phenyl)-3-[2-(3-fluorophenyl)-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]propanamide
N-(3-chloro-4-fluorophenyl)-3-[2-(3-fluorophenyl)-5,7-dimethyl-6-pyrazolo[1,5-a]pyrimidinyl]propanamide
N-(3-chloro-4-fluoro-phenyl)-3-[2-(3-fluorophenyl)-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0067	0.0712
Onchocerca volvulus		0.0025	0.0067	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0067	0.0712
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0067	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1269	0.3874
Onchocerca volvulus		0.0025	0.0067	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0067	0.0712
Loa Loa (eye worm)	cathepsin B	0.0097	0.0945	0.2885
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0067	0.0205
Schistosoma mansoni	cathepsin F (C01 family)	0.0025	0.0067	0.0205
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0123	0.1269	0.1209
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0067	0.0712
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0578	0.1765
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0067	0.0205
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0026	0.0074	0.0225
Loa Loa (eye worm)	cysteine protease	0.0025	0.0067	0.0205
Onchocerca volvulus	Cathepsin F homolog	0.0025	0.0067	1
Loa Loa (eye worm)	glutamate receptor	0.0039	0.0242	0.0738
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0025	0.0067	0.0205
Brugia malayi	TAR-binding protein	0.0067	0.0578	0.1765
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0286	0.3275	1
Leishmania major	cathepsin L-like protease	0.0072	0.0639	0.6517
Leishmania major	cathepsin L-like protease	0.0072	0.0639	0.6517
Brugia malayi	Metabotropic glutamate receptor precursor.	0.01	0.0985	0.3009
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0097	0.0945	1
Schistosoma mansoni	hypothetical protein	0.0036	0.02	0.061
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0025	0.0067	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0578	0.1765
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0067	0.0578	0.1765
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0067	0.0712
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3275	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0067	0.0712
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0067	0.0712
Giardia lamblia	Cathepsin B precursor	0.0097	0.0945	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0067	0.0712
Echinococcus multilocularis	cathepsin b	0.0286	0.3275	0.3229
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0067	0.0205
Schistosoma mansoni	metabotropic glutamate receptor	0.0049	0.0357	0.109
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0286	0.3275	1
Echinococcus granulosus	cathepsin b	0.0286	0.3275	1
Plasmodium vivax	vivapain-2	0.0025	0.0067	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0286	0.3275	1
Brugia malayi	metabotropic glutamate receptor type 2	0.0049	0.0357	0.109
Loa Loa (eye worm)	hypothetical protein	0.0036	0.02	0.061
Trypanosoma cruzi	cysteine peptidase, putative	0.0072	0.0639	0.1783
Giardia lamblia	Cathepsin B precursor	0.0097	0.0945	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0067	0.0712
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0286	0.3275	1
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0067	0.0205
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0025	0.0067	0.0205
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0404	0.1233
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0067	1
Schistosoma mansoni	metabotropic glutamate receptor	0.0084	0.0786	0.2401
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0578	0.1765
Onchocerca volvulus		0.0025	0.0067	1
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0578	0.1765
Onchocerca volvulus	Cathepsin L homolog	0.0025	0.0067	1
Loa Loa (eye worm)	glutamate receptor	0.01	0.0985	0.3009
Loa Loa (eye worm)	TAR-binding protein	0.0067	0.0578	0.1765
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0067	0.0712
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0067	0.0712
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0026	0.0074	0.0225
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0067	0.0205
Schistosoma mansoni	cathepsin F (C01 family)	0.0025	0.0067	0.0205
Brugia malayi	RNA recognition motif domain containing protein	0.0067	0.0578	0.1765
Loa Loa (eye worm)	RNA binding protein	0.0067	0.0578	0.1765
Trypanosoma cruzi	major cysteine proteinase, putative	0.0058	0.0473	0.1265
Entamoeba histolytica	cysteine proteinase, putative	0.0025	0.0067	1
Plasmodium vivax	vivapain-2	0.0025	0.0067	0.5
Echinococcus multilocularis	tar DNA binding protein	0.0067	0.0578	0.0514
Onchocerca volvulus		0.0025	0.0067	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0026	0.0074	0.0225
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0067	0.0205
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0067	0.0712
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0067	0.0712
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0067	0.0712
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0025	0.0067	0.5
Trypanosoma cruzi	cruzipain precursor, putative	0.0072	0.0639	0.1783
Loa Loa (eye worm)	fibroinase	0.0025	0.0067	0.0205
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0097	0.0945	0.2735
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0067	0.0712
Onchocerca volvulus		0.0025	0.0067	1
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0084	0.0786	0.0724
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0067	0.0712
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0067	0.0712
Echinococcus granulosus	tar DNA binding protein	0.0067	0.0578	0.1765
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0404	0.1233
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0025	0.0067	0.5
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0084	0.0786	0.2401
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0074	0.0225
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0025	0.0067	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0404	0.1233
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0123	0.1269	0.3874
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0067	0.0712
Trypanosoma cruzi	cysteine peptidase, putative	0.0072	0.0639	0.1783
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0025	0.0067	0.0205
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0067	0.0712
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0097	0.0945	0.2885
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0066	0.0572	0.1573
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.0067	0.0205
Toxoplasma gondii	cathepsin B	0.0097	0.0945	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0072	0.0639	0.1783
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0097	0.0945	1
Entamoeba histolytica	cysteine proteinase, putative	0.0025	0.0067	1
Brugia malayi	RNA binding protein	0.0067	0.0578	0.1765
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0025	0.0067	0.0712
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0286	0.3275	1
Echinococcus multilocularis	cathepsin b	0.0286	0.3275	0.3229
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0097	0.0945	1
Echinococcus granulosus	cathepsin b	0.0286	0.3275	1
Onchocerca volvulus	Cathepsin L homolog	0.0025	0.0067	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0286	0.3275	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0067	0.0712
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0067	0.0712
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0114	0.1153	0.3522
Leishmania major	cathepsin L-like protease	0.0072	0.0639	0.6517
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0091	0.087	0.2657
Onchocerca volvulus		0.0025	0.0067	1
Onchocerca volvulus		0.0025	0.0067	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0404	0.1233
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0025	0.0067	0.0712
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0067	0.0712
Giardia lamblia	Cathepsin B precursor	0.0097	0.0945	0.5
Loa Loa (eye worm)	ctsf protein	0.0025	0.0067	0.0205
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.02	0.061
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0067	0.0712
Echinococcus granulosus	cathepsin l1	0.0025	0.0067	0.0205
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0578	0.1765

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 837321