Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0073 | 1 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0019 | 0.085 | 0.0836 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0014 | 0.0128 | 0.0112 |
Treponema pallidum | NADH oxidase | 0.0025 | 0.1979 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0591 | 0.0575 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0025 | 0.1979 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0073 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0073 | 1 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0025 | 0.1979 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0025 | 0.1979 | 0.5 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Echinococcus multilocularis | C type lectin domian containing protein | 0.0014 | 0.0016 | 0.0016 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0073 | 1 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0019 | 0.085 | 0.0836 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0025 | 0.1979 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0128 | 0.0112 |
Plasmodium falciparum | thioredoxin reductase | 0.0025 | 0.1979 | 0.1966 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0025 | 0.1979 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0014 | 0.0128 | 0.0128 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0025 | 0.1979 | 0.1966 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0025 | 0.1979 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0073 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Echinococcus granulosus | c4b binding protein beta chain | 0.0014 | 0.0016 | 0.0016 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0073 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Toxoplasma gondii | thioredoxin reductase | 0.0073 | 1 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0025 | 0.1979 | 0.5 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1256 | 0.1242 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Echinococcus multilocularis | c4b binding protein beta chain | 0.0014 | 0.0016 | 0.0016 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0025 | 0.1979 | 0.1966 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0025 | 0.1979 | 0.5 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0025 | 0.1979 | 0.1966 |
Leishmania major | trypanothione reductase | 0.0073 | 1 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0017 | 0.0591 | 0.0591 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0273 | 0.0257 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0025 | 0.1979 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0073 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0073 | 1 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0025 | 0.1979 | 0.1979 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0025 | 0.1979 | 0.1966 |
Brugia malayi | Thioredoxin reductase | 0.0073 | 1 | 1 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0021 | 0.1256 | 0.1242 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0014 | 0.0128 | 0.0112 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0025 | 0.1979 | 0.5 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0025 | 0.1979 | 0.1966 |
Plasmodium vivax | glutathione reductase, putative | 0.0073 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0025 | 0.1979 | 0.1966 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0591 | 0.0575 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0025 | 0.1979 | 0.1979 |
Plasmodium falciparum | thioredoxin reductase | 0.0073 | 1 | 1 |
Echinococcus granulosus | C type lectin domian containing protein | 0.0014 | 0.0016 | 0.0016 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0025 | 0.1979 | 0.1966 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0025 | 0.1979 | 0.1966 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0014 | 0.0128 | 0.0128 |
Echinococcus multilocularis | roundabout 2 | 0.0017 | 0.0591 | 0.0591 |
Schistosoma mansoni | c4b-binding protein beta chain | 0.0014 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0073 | 1 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0025 | 0.1979 | 0.1979 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.