Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | carbonic anhydrase family protein, putative | 0.6133 | 0.41 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.6133 | 0.41 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2068 | 0.0431 | 0.5 |
Onchocerca volvulus | Putative sulfate transporter | 0.2044 | 0.041 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.2068 | 0.0431 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2068 | 0.0431 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 1.267 | 1 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.2068 | 0.0431 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.9738 | 0.7353 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.6133 | 0.41 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.6133 | 0.41 | 1 |
Onchocerca volvulus | 0.2044 | 0.041 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 1.267 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.5294 | 0.3342 | 0.3975 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.2068 | 0.0431 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.3201 | 0.1454 | 0.1138 |
Echinococcus multilocularis | carbonic anhydrase II | 0.2068 | 0.0431 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.2068 | 0.0431 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2068 | 0.0431 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.2068 | 0.0431 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.