Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | prostaglandin-E synthase | 0.0822 | 0.5 | 0.5 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.0822 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0822 | 0.5 | 0.5 | |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.0822 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0822 | 0.5 | 0.5 |
Trypanosoma brucei | Prostaglandin E synthase | 0.0822 | 0.5 | 0.5 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.0822 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 4.17 | Calculated partition coefficient (clogP) | ChEMBL. | 12723954 |
EC50 (functional) | = 46 nM | Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay. | ChEMBL. | 12723954 |
Emax (binding) | = 86 | Emax | ChEMBL. | 12723954 |
NA (functional) | 0 | Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay. | ChEMBL. | 12723954 |
NA (functional) | 0 | Effective concentration required against gastrin releasing peptide receptor (GRP-R) in CHO cells by using FLIPR assay. | ChEMBL. | 12723954 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.