Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Integrin alpha pat-2 precursor | 0.2255 | 0.3965 | 0.3965 |
Echinococcus granulosus | integrin beta 2 | 0.3422 | 0.6944 | 1 |
Schistosoma mansoni | integrin alpha | 0.2255 | 0.3965 | 0.728 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.3476 | 0.7083 | 0.7083 |
Schistosoma mansoni | integrin beta subunit | 0.272 | 0.5152 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.177 | 0.2728 | 0.2728 |
Loa Loa (eye worm) | hypothetical protein | 0.1706 | 0.2563 | 0.2563 |
Echinococcus granulosus | integrin alpha 3 | 0.1729 | 0.2621 | 0.2977 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.1706 | 0.2563 | 0.2563 |
Loa Loa (eye worm) | integrin beta-2 | 0.4619 | 1 | 1 |
Echinococcus multilocularis | integrin alpha 3 | 0.1729 | 0.2621 | 0.2977 |
Loa Loa (eye worm) | hypothetical protein | 0.1244 | 0.1384 | 0.1384 |
Echinococcus multilocularis | integrin beta 2 | 0.3422 | 0.6944 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.