Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Salmonella enterica subsp. enterica serovar Typhi | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Lactobacillus casei | Dihydrofolate reductase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 7.77 | Inhibitory activity against dihydrofolate reductase | ChEMBL. | 11495588 |
Activity (binding) | = 7.77 | Activity against dihydrofolate reductase of Escherichia coli strain MB 1428 | ChEMBL. | 1507206 |
Ki (binding) | = 4.19 | Inhibitory activity against chicken liver dihydrofolate reductase | ChEMBL. | 2502631 |
Ki (binding) | = 6.54 | Inhibitory activity against Lactobacillus casei dihydrofolate reductase | ChEMBL. | 2502631 |
Ki (binding) | = 7.77 | Inhibitory activity against E. coli dihydrofolate reductase | ChEMBL. | 1899453 |
Log (binding) | = 7.77 1/Ki | Inhibitory activity against E. coli dihydrofolate reductase | ChEMBL. | 1899453 |
Log 1/C (functional) | = 4.3 | The logarithm of the inverse of the concentration (log 1/C) for the inhibition of E. coli MB 1428 growth by 80% | ChEMBL. | 3276891 |
Log 1/C (functional) | = 5.82 | The logarithm of the inverse of the concentration (log 1/C) for the inhibition of Escherichia coli 1515 (E. coli) growth by 80% | ChEMBL. | 3276891 |
Log 1/C (functional) | = 4.3 | The logarithm of the inverse of the concentration (log 1/C) for the inhibition of E. coli MB 1428 growth by 80% | ChEMBL. | 3276891 |
Log 1/C (functional) | = 5.82 | The logarithm of the inverse of the concentration (log 1/C) for the inhibition of Escherichia coli 1515 (E. coli) growth by 80% | ChEMBL. | 3276891 |
Log 1/Ki (binding) | = 4.19 | Inhibitory activity against chicken liver dihydrofolate reductase | ChEMBL. | 2502631 |
Log 1/Ki (binding) | = 6.54 | Inhibitory activity against Lactobacillus casei dihydrofolate reductase | ChEMBL. | 2502631 |
Log 1/Ki app (binding) | = 9.25 | Apparent inhibitory (log 1/Ki) activity against Escherichia coli dihydrofolate reductase | ChEMBL. | 3276891 |
logD (ADMET) | = -1.87 | Partition coefficient (logD) (aqueous phase 0.1 N HCl) | ChEMBL. | 2502631 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
5 literature references were collected for this gene.