Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0091 | 0.161 | 0.5 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0223 | 0.5552 | 1 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0223 | 0.5552 | 0.4699 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0223 | 0.5552 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.4558 | 0.3514 |
Echinococcus granulosus | serotonin transporter | 0.0091 | 0.161 | 0.2899 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0371 | 1 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0223 | 0.5552 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0223 | 0.5552 | 0.4699 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0371 | 1 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0371 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 1 | 1 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0223 | 0.5552 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0091 | 0.161 | 0.2899 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency ratio (binding) | = 5.5 | Inhibition of V-ATPase-driven proton transport in membrane vesicles derived from chicken osteoclasts (cOc); Potency ratio expressed as IC50 of compound/IC50 of baf A1 | ChEMBL. | 9599238 |
Potency ratio (binding) | = 6.7 | Inhibition of V-ATPase-driven proton transport in membrane vesicles derived from bovine chromaffin granules (bCG); Potency ratio expressed as IC50 of compound/IC50 of baf A1 | ChEMBL. | 9599238 |
Potency ratio (binding) | = 5.5 | Inhibition of V-ATPase-driven proton transport in membrane vesicles derived from chicken osteoclasts (cOc); Potency ratio expressed as IC50 of compound/IC50 of baf A1 | ChEMBL. | 9599238 |
Potency ratio (binding) | = 6.7 | Inhibition of V-ATPase-driven proton transport in membrane vesicles derived from bovine chromaffin granules (bCG); Potency ratio expressed as IC50 of compound/IC50 of baf A1 | ChEMBL. | 9599238 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.