Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | malate dehydrogenase, putative | 0.0281 | 1 | 1 |
Echinococcus multilocularis | L lactate dehydrogenase B chain | 0.0281 | 1 | 1 |
Trypanosoma cruzi | cytosolic malate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Trypanosoma cruzi | cytosolic malate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Echinococcus multilocularis | malate dehydrogenase | 0.0109 | 0.3162 | 0.3162 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Schistosoma mansoni | L-lactate dehydrogenase | 0.0109 | 0.3162 | 0.3162 |
Mycobacterium ulcerans | malate dehydrogenase | 0.0109 | 0.3162 | 0.5 |
Trypanosoma brucei | glycosomal malate dehydrogenase | 0.0109 | 0.3162 | 1 |
Loa Loa (eye worm) | malate dehydrogenase | 0.0109 | 0.3162 | 0.3162 |
Mycobacterium leprae | PROBABLE MALATE DEHYDROGENASE MDH | 0.0109 | 0.3162 | 0.5 |
Leishmania major | malate dehydrogenase, putative | 0.0281 | 1 | 1 |
Schistosoma mansoni | malate dehydrogenase | 0.0109 | 0.3162 | 0.3162 |
Trypanosoma brucei | cytosolic malate dehydrogenase | 0.0109 | 0.3162 | 1 |
Echinococcus granulosus | cytosolic malate dehydrogenase | 0.0109 | 0.3162 | 0.3162 |
Leishmania major | cytosolic malate dehydrogenase | 0.0109 | 0.3162 | 0.3162 |
Schistosoma mansoni | L-lactate dehydrogenase | 0.0281 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Toxoplasma gondii | lactate dehydrogenase LDH2 | 0.0281 | 1 | 1 |
Echinococcus multilocularis | malate dehydrogenase | 0.0109 | 0.3162 | 0.3162 |
Echinococcus granulosus | lactate dehydrogenase protein | 0.0281 | 1 | 1 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Schistosoma mansoni | malate dehydrogenase | 0.0109 | 0.3162 | 0.3162 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Schistosoma mansoni | malate dehydrogenase | 0.0109 | 0.3162 | 0.3162 |
Leishmania major | glycosomal malate dehydrogenase | 0.0109 | 0.3162 | 0.3162 |
Trypanosoma brucei | mitochondrial malate dehydrogenase | 0.0109 | 0.3162 | 1 |
Echinococcus multilocularis | cytosolic malate dehydrogenase | 0.0109 | 0.3162 | 0.3162 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Leishmania major | malate dehydrogenase, putative | 0.0109 | 0.3162 | 0.3162 |
Loa Loa (eye worm) | malate dehydrogenase | 0.0109 | 0.3162 | 0.3162 |
Trypanosoma cruzi | glycosomal malate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Entamoeba histolytica | malate dehydrogenase, putative | 0.0109 | 0.3162 | 0.3162 |
Plasmodium falciparum | lactate dehydrogenase, putative | 0.0109 | 0.3162 | 0.3162 |
Schistosoma mansoni | malate dehydrogenase | 0.0281 | 1 | 1 |
Toxoplasma gondii | malate dehydrogenase MDH | 0.0281 | 1 | 1 |
Echinococcus granulosus | cytosolic malate dehydrogenase | 0.0109 | 0.3162 | 0.3162 |
Entamoeba histolytica | malate dehydrogenase,cytoplasmic, putative | 0.0109 | 0.3162 | 0.3162 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0053 | 0.0933 | 0.2949 |
Plasmodium falciparum | L-lactate dehydrogenase | 0.0281 | 1 | 1 |
Chlamydia trachomatis | malate dehydrogenase | 0.0109 | 0.3162 | 0.5 |
Echinococcus granulosus | L lactate dehydrogenase B chain | 0.0281 | 1 | 1 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0281 | 1 | 1 |
Leishmania major | mitochondrial malate dehydrogenase | 0.0109 | 0.3162 | 0.3162 |
Trypanosoma cruzi | glycosomal malate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0053 | 0.0933 | 0.2949 |
Trypanosoma brucei | malate dehydrogenase-related | 0.0109 | 0.3162 | 1 |
Brugia malayi | Malate dehydrogenase, cytoplasmic | 0.0109 | 0.3162 | 0.3162 |
Echinococcus multilocularis | cytosolic malate dehydrogenase | 0.0109 | 0.3162 | 0.3162 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Echinococcus granulosus | lactate dehydrogenase a | 0.0281 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Plasmodium vivax | lactate dehydrogenase | 0.0281 | 1 | 1 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0281 | 1 | 1 |
Brugia malayi | Probable malate dehydrogenase, mitochondrial precursor | 0.0109 | 0.3162 | 0.3162 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Echinococcus multilocularis | L lactate dehydrogenase | 0.0172 | 0.5652 | 0.5652 |
Wolbachia endosymbiont of Brugia malayi | malate dehydrogenase | 0.0281 | 1 | 0.5 |
Plasmodium vivax | lactate/malate dehydrogenase, putative | 0.0109 | 0.3162 | 0.3162 |
Mycobacterium tuberculosis | Probable malate dehydrogenase Mdh | 0.0109 | 0.3162 | 0.5 |
Trypanosoma cruzi | malate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 1 | 1 |
Leishmania major | malate dehydrogenase | 0.0109 | 0.3162 | 0.3162 |
Toxoplasma gondii | lactate dehydrogenase LDH1 | 0.0281 | 1 | 1 |
Echinococcus multilocularis | lactate dehydrogenase protein | 0.0281 | 1 | 1 |
Echinococcus granulosus | malate dehydrogenase | 0.0109 | 0.3162 | 0.3162 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Plasmodium vivax | malate dehydrogenase, putative | 0.0281 | 1 | 1 |
Trypanosoma cruzi | mitochondrial malate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Giardia lamblia | Malate dehydrogenase | 0.0109 | 0.3162 | 1 |
Echinococcus granulosus | L lactate dehydrogenase | 0.0172 | 0.5652 | 0.5652 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Trypanosoma cruzi | malate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Echinococcus granulosus | malate dehydrogenase | 0.0109 | 0.3162 | 0.3162 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0281 | 1 | 1 |
Plasmodium falciparum | malate dehydrogenase | 0.0281 | 1 | 1 |
Echinococcus granulosus | lactate dehydrogenase a | 0.0281 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0109 | 0.3162 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | > 10 uM | Tested for 50% growth inhibitory concentration by using MCF-7 cell lines. | ChEMBL. | 11960501 |
IC50 (functional) | = 5.4 uM | Inhibition of tubulin polymerization in human ovarian cancer cell lines | ChEMBL. | 11960501 |
Inhibition (functional) | = 12 % | Tested for colchicine binding inhibition, using human ovarian cancer cell lines (at 5 microM ) | ChEMBL. | 11960501 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.