Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0216 | 0.2139 | 0.2845 | |
Trypanosoma brucei | metacaspase MCA2 | 0.0463 | 0.4801 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.1694 | 0.2379 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.1694 | 0.2379 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0463 | 0.4801 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0157 | 0.0221 |
Echinococcus granulosus | caspase | 0.0844 | 0.8896 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0463 | 0.4801 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0463 | 0.4801 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0463 | 0.4801 | 0.5 |
Leishmania major | metacaspase, putative | 0.0463 | 0.4801 | 1 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0463 | 0.4801 | 1 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0157 | 0.0221 |
Echinococcus granulosus | caspase 3 | 0.0381 | 0.3914 | 0.4299 |
Trypanosoma cruzi | metacaspase, putative | 0.0463 | 0.4801 | 1 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0844 | 0.8896 | 1 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0216 | 0.2139 | 0.2013 |
Trypanosoma brucei | metacaspase MCA3 | 0.0463 | 0.4801 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0463 | 0.4801 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0157 | 0.0221 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0463 | 0.4801 | 1 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0679 | 0.7121 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0463 | 0.4801 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.0174 | 0.1694 | 0.1562 |
Brugia malayi | hypothetical protein | 0.0216 | 0.2139 | 0.3003 |
Plasmodium vivax | hypothetical protein, conserved | 0.0463 | 0.4801 | 1 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0023 | 0.0032 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0463 | 0.4801 | 0.5 |
Trypanosoma brucei | metacaspase 5, putative | 0.0463 | 0.4801 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0174 | 0.1694 | 0.1562 |
Echinococcus multilocularis | caspase 2 | 0.0679 | 0.7121 | 0.7075 |
Loa Loa (eye worm) | hypothetical protein | 0.0463 | 0.4801 | 0.6742 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0463 | 0.4801 | 0.5 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0463 | 0.4801 | 0.6742 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0157 | 0.0221 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0463 | 0.4801 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0463 | 0.4801 | 0.5 |
Trypanosoma brucei | metacaspase | 0.0463 | 0.4801 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0463 | 0.4801 | 0.5 |
Brugia malayi | Cell death protein 3 precursor | 0.0679 | 0.7121 | 1 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0135 | 0.019 |
Brugia malayi | Muscleblind-like protein | 0.0174 | 0.1694 | 0.2379 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0844 | 0.8896 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0216 | 0.2139 | 0.2267 |
Echinococcus granulosus | caspase 2 | 0.0679 | 0.7121 | 0.7969 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0844 | 0.8896 | 1 |
Plasmodium falciparum | metacaspase-like protein | 0.0463 | 0.4801 | 1 |
Echinococcus multilocularis | caspase | 0.0844 | 0.8896 | 0.8879 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0463 | 0.4801 | 0.5 |
Trypanosoma brucei | Metacaspase-4 | 0.0463 | 0.4801 | 1 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0463 | 0.4801 | 0.5314 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.2139 | 0.3003 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0151 | 0.0212 |
Trypanosoma cruzi | metacaspase, putative | 0.0463 | 0.4801 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0174 | 0.1694 | 0.1759 |
Trypanosoma cruzi | metacaspase, putative | 0.0463 | 0.4801 | 1 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0844 | 0.8896 | 0.8879 |
Plasmodium vivax | metacaspase 1, putative | 0.0463 | 0.4801 | 1 |
Echinococcus multilocularis | caspase 8 | 0.0463 | 0.4801 | 0.4718 |
Loa Loa (eye worm) | hypothetical protein | 0.0679 | 0.7121 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0463 | 0.4801 | 0.5 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0463 | 0.4801 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.0463 | 0.4801 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0135 | 0.019 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0463 | 0.4801 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0157 | 0.0221 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0216 | 0.2139 | 0.2267 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0463 | 0.4801 | 1 |
Plasmodium falciparum | metacaspase 1 | 0.0463 | 0.4801 | 1 |
Echinococcus multilocularis | caspase 3 | 0.0381 | 0.3914 | 0.3817 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0463 | 0.4801 | 0.5 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0679 | 0.7121 | 0.7969 |
Echinococcus granulosus | caspase 8 | 0.0463 | 0.4801 | 0.5314 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0463 | 0.4801 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.