Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0731 | 0.073 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0731 | 0.073 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0081 | 0.5994 | 1 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0039 | 0.2435 | 0.3731 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0081 | 0.5994 | 1 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0081 | 0.5994 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0731 | 0.073 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0081 | 0.5994 | 1 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0043 | 0.2775 | 0.3883 |
Leishmania major | guanosine monophosphate reductase | 0.0081 | 0.5994 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0731 | 0.0731 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0081 | 0.5994 | 0.5994 |
Brugia malayi | GMP reductase | 0.0034 | 0.2033 | 0.1772 |
Loa Loa (eye worm) | GMP reductase | 0.0034 | 0.2033 | 0.2033 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0081 | 0.5994 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0731 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0731 | 0.0428 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0043 | 0.2775 | 0.0954 |
Trypanosoma cruzi | GMP reductase | 0.0081 | 0.5994 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0731 | 0.5 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0076 | 0.5592 | 0.9291 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0076 | 0.5592 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0034 | 0.2033 | 0.1772 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0731 | 0.073 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.0317 | 0.0317 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0731 | 0.5 |
Loa Loa (eye worm) | STAT protein | 0.0129 | 1 | 1 |
Onchocerca volvulus | Putative GMP reductase | 0.0034 | 0.2033 | 0.5 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0081 | 0.5994 | 1 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0076 | 0.5592 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0081 | 0.5994 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0731 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.0317 | 0.0317 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0013 | 0.0317 | 0.0317 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0081 | 0.5994 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0731 | 0.073 |
Trypanosoma brucei | GMP reductase | 0.0081 | 0.5994 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0034 | 0.2033 | 0.1772 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0731 | 0.5 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0081 | 0.5994 | 1 |
Toxoplasma gondii | IMP dehydrogenas | 0.0081 | 0.5994 | 1 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0081 | 0.5994 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0081 | 0.5994 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0081 | 0.5994 | 0.5863 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0081 | 0.5994 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0081 | 0.5994 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.