Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.2478 | 1 | 1 |
Onchocerca volvulus | 0.0419 | 0 | 0.5 | |
Onchocerca volvulus | 0.0419 | 0 | 0.5 | |
Onchocerca volvulus | 0.0419 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.2478 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0419 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2478 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.2478 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2478 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2478 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2478 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0419 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2478 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0419 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.2478 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2478 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0419 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2478 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0419 | 0 | 0.5 |
Onchocerca volvulus | 0.0419 | 0 | 0.5 | |
Onchocerca volvulus | 0.0419 | 0 | 0.5 | |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0424 | 0.0028 | 0.0028 |
Echinococcus multilocularis | acetylcholinesterase | 0.2478 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0419 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.