Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0031 | 0.533 | 0.4775 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.1062 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.3135 | 0.3135 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.1062 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.3135 | 0.2319 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.3135 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.1062 | 0.1062 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.1062 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.1062 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0045 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.3135 | 0.2319 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.3135 | 0.2319 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0031 | 0.533 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.3135 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0031 | 0.533 | 0.4775 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0045 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.1062 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.1062 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0045 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.1062 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.3135 | 0.2319 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.3135 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.3135 | 0.2319 |
Echinococcus multilocularis | dna polymerase eta | 0.0045 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0045 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0045 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.1062 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.