Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cytochrome p450-like protein | 0.0039 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0039 | 1 | 0.5 |
Echinococcus multilocularis | sodium channel protein | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | sodium channel protein | 0.0032 | 0 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0039 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0039 | 1 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0039 | 1 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0039 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0039 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0039 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0039 | 1 | 0.5 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0032 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.