Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.2706 | 0.2491 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0287 | 0.0363 |
Trypanosoma brucei | protein kinase, putative | 0.0052 | 0.789 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.4242 | 0.5377 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.2706 | 0.343 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.789 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0052 | 0.789 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.789 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.789 | 0.5 |
Schistosoma mansoni | lamin | 0.0028 | 0.2706 | 0.2491 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 1 | 0.5 |
Brugia malayi | MAP kinase sur-1 | 0.0052 | 0.789 | 1 |
Onchocerca volvulus | 0.0028 | 0.2706 | 0.5 | |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.2706 | 0.343 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.2706 | 0.2491 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.4242 | 0.5377 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0052 | 0.789 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0052 | 0.789 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.7651 | 0.9698 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.789 | 0.7827 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0052 | 0.789 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0052 | 0.789 | 0.7827 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0028 | 0.2706 | 0.2491 |
Echinococcus granulosus | lamin | 0.0028 | 0.2706 | 0.2491 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.2706 | 0.343 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.2706 | 0.2491 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0052 | 0.789 | 0.5 |
Schistosoma mansoni | lamin | 0.0028 | 0.2706 | 0.2491 |
Onchocerca volvulus | 0.0028 | 0.2706 | 0.5 | |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 1 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0052 | 0.789 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.2706 | 0.343 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.7651 | 0.9698 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0052 | 0.789 | 0.7827 |
Echinococcus multilocularis | lamin | 0.0028 | 0.2706 | 0.2491 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.4242 | 0.4073 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.2706 | 0.343 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0287 | 0.0363 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0287 | 0.0363 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.7651 | 0.9698 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.2706 | 0.2491 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0052 | 0.789 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 1 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0287 | 0.0363 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.7651 | 0.9698 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0052 | 0.789 | 0.7827 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2599 | 0.3295 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.789 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0052 | 0.789 | 0.7827 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.