Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.5968 | 0.7725 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0055 | 0.7093 | 0.6299 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0055 | 0.7093 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.5968 | 0.8413 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.2843 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.2843 | 0.1408 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0055 | 0.7093 | 1 |
Onchocerca volvulus | 0.007 | 1 | 0.5 | |
Brugia malayi | acyl-CoA desaturase | 0.0055 | 0.7093 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.2146 | 0.3026 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.007 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.5968 | 0.7725 |
Onchocerca volvulus | 0.007 | 1 | 0.5 | |
Leishmania major | fatty-acid desaturase, putative | 0.007 | 1 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0055 | 0.7093 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.2843 | 0.4007 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.007 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.2146 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.5968 | 0.8413 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0055 | 0.7093 | 0.6299 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0891 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.