Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Cyclin dependent kinase 2 associated protein | 0.2855 | 0.3025 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.8711 | 0.9323 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.002 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0102 | 0.011 |
Brugia malayi | Protein kinase domain containing protein | 0.8711 | 0.9323 | 0.9323 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0102 | 0.011 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.002 | 0.002 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0136 | 0.0102 | 0.011 |
Onchocerca volvulus | Diphthamide biosynthesis protein 7 homolog | 0.2855 | 0.3025 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.002 | 0.0022 |
Brugia malayi | GnHR receptor homolog | 0.1386 | 0.1446 | 0.1446 |
Loa Loa (eye worm) | hypothetical protein | 0.2855 | 0.3025 | 0.3245 |
Echinococcus multilocularis | Cyclin dependent kinase 2 associated protein | 0.2855 | 0.3025 | 1 |
Schistosoma mansoni | deleted in oral cancer 1/cdk2-associated protein-like | 0.2855 | 0.3025 | 0.3245 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.002 | 0.002 |
Schistosoma mansoni | serine/threonine protein kinase | 0.8711 | 0.9323 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.