Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0613 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.02 | 0.0152 |
Leishmania major | protein kinase, putative | 0.0047 | 0.02 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0613 | 1 | 1 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0133 | 0.1695 | 0.2772 |
Mycobacterium ulcerans | putative regulatory protein | 0.0133 | 0.1695 | 0.1603 |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.528 | 0.8647 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0041 | 0.0109 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0613 | 1 | 1 |
Leishmania major | protein kinase, putative | 0.0047 | 0.02 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0613 | 1 | 1 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.034 | 0.528 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0613 | 1 | 1 |
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.0048 | 0.0227 | 0.0197 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0184 | 0.2573 | 0.4873 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0047 | 0.02 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.5307 | 0.8692 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0172 | 0.2362 | 0.3767 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0041 | 0.0109 | 0.0179 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0041 | 0.0109 | 0.5 |
Brugia malayi | hypothetical protein | 0.0047 | 0.02 | 0.0379 |
Onchocerca volvulus | 0.0387 | 0.6089 | 1 | |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0041 | 0.0109 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.6089 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0047 | 0.02 | 1 |
Schistosoma mansoni | dihydropteridine reductase | 0.0041 | 0.0109 | 0.013 |
Echinococcus granulosus | Aryl hydrocarbon receptor nuclear | 0.0048 | 0.0227 | 0.0371 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0388 | 0.6116 | 1 |
Onchocerca volvulus | 0.0135 | 0.1722 | 0.2697 | |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0613 | 1 | 1 |
Leishmania major | PAS-domain containing phosphoglycerate kinase, putative | 0.0047 | 0.02 | 1 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0041 | 0.0109 | 0.0179 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0047 | 0.02 | 1 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0047 | 0.02 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0184 | 0.2573 | 0.412 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0047 | 0.02 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0613 | 1 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0041 | 0.0109 | 0.0207 |
Trypanosoma brucei | pteridine reductase 1 | 0.0041 | 0.0109 | 0.5 |
Schistosoma mansoni | single-minded | 0.018 | 0.2504 | 0.2974 |
Echinococcus granulosus | single minded 2 | 0.0133 | 0.1695 | 0.2772 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0521 | 0.842 | 1 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0388 | 0.6116 | 1 |
Brugia malayi | bHLH-PAS transcription factor | 0.0133 | 0.1695 | 0.3211 |
Brugia malayi | PAS domain containing protein | 0.018 | 0.2504 | 0.4743 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0613 | 1 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0041 | 0.0109 | 0.0207 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0041 | 0.0109 | 1 |
Mycobacterium leprae | Possible regulatory protein | 0.0047 | 0.02 | 0.0092 |
Echinococcus multilocularis | Aryl hydrocarbon receptor nuclear | 0.0048 | 0.0227 | 0.0371 |
Chlamydia trachomatis | two component regulatory system sensor histidine kinase | 0.0047 | 0.02 | 0.0092 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0047 | 0.02 | 1 |
Onchocerca volvulus | 0.0169 | 0.2312 | 0.3683 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.