Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carbonic anhydrase II | 0.2069 | 0.0205 | 0.5 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.3261 | 0.1075 | 0.1263 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.2069 | 0.0205 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 1.3448 | 0.8508 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.2069 | 0.0205 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2069 | 0.0205 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.3833 | 0.1492 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.3833 | 0.1492 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 1.5493 | 1 | 0.5 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.3833 | 0.1492 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.3833 | 0.1492 | 1 |
Onchocerca volvulus | 0.2823 | 0.0755 | 0.5 | |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.2069 | 0.0205 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.2069 | 0.0205 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.2069 | 0.0205 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.5305 | 0.2566 | 0.3016 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2069 | 0.0205 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2069 | 0.0205 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 1.5493 | 1 | 0.5 |
Onchocerca volvulus | Putative sulfate transporter | 0.2823 | 0.0755 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.