Detailed information for compound 846551

Basic information

Technical information
  • TDR Targets ID: 846551
  • Name: 2-(1-oxopyrrolo[1,2-d][1,2,4]triazin-2-yl)pro panoic acid
  • MW: 207.186 | Formula: C9H9N3O3
  • H donors: 1 H acceptors: 3 LogP: 0.39 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(n1ncn2c(c1=O)ccc2)C
  • InChi: 1S/C9H9N3O3/c1-6(9(14)15)12-8(13)7-3-2-4-11(7)5-10-12/h2-6H,1H3,(H,14,15)
  • InChiKey: OGZHNSRMTLMTQV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(1-oxo-2-pyrrolo[1,2-d][1,2,4]triazinyl)propanoic acid
  • 2-(1-ketopyrrolo[1,2-d][1,2,4]triazin-2-yl)propionic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.8441 1
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.003 0.4245 0.5
Trichomonas vaginalis heat shock protein, putative 0.0038 0.8441 0.8363
Leishmania major heat shock protein 83-1 0.0038 0.8441 0.729
Leishmania major heat shock protein 83-1 0.0038 0.8441 0.729
Leishmania major heat shock protein 83-1 0.0038 0.8441 0.729
Leishmania major heat shock protein 83-1 0.0038 0.8441 0.729
Schistosoma mansoni transcription factor btf3 0.0041 1 1
Leishmania major heat shock protein 83-1 0.0038 0.8441 0.729
Leishmania major heat shock protein 83-1 0.0038 0.8441 0.729
Leishmania major heat shock protein 83-1 0.0038 0.8441 0.729
Leishmania major heat shock protein 83-1 0.0038 0.8441 0.729
Leishmania major heat shock protein 83-1 0.0038 0.8441 0.729
Trichomonas vaginalis heat shock protein, putative 0.003 0.4245 0.3957
Echinococcus granulosus heat shock protein 0.0038 0.8441 0.729
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.003 0.4245 0.5
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.8441 0.8441
Treponema pallidum heat shock protein 90 0.003 0.4245 0.5
Mycobacterium ulcerans heat shock protein 90 0.003 0.4245 0.5
Entamoeba histolytica transcription factor BTF3, putative 0.0041 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 1 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0038 0.8441 0.8441
Leishmania major basic transcription factor 3a, putative 0.0041 1 1
Echinococcus multilocularis transcription factor btf3 0.0041 1 1
Echinococcus granulosus heat shock protein 90 0.0038 0.8441 0.729
Leishmania major heat shock protein 83-1 0.0038 0.8441 0.729
Trypanosoma cruzi transcription factor btf3, putative 0.0041 1 1
Leishmania major heat shock protein 83-1 0.0038 0.8441 0.729
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.8441 0.8441
Echinococcus granulosus transcription factor btf3 0.0041 1 1
Leishmania major heat shock protein 83-1 0.0038 0.8441 0.729
Loa Loa (eye worm) ICD-1 protein 0.0041 1 1
Plasmodium vivax basic transcription factor 3b, putative 0.0041 1 1
Leishmania major heat shock protein 83-1 0.0038 0.8441 0.729
Echinococcus multilocularis heat shock protein 90 0.0038 0.8441 0.729
Trypanosoma cruzi transcription factor btf3, putative 0.0041 1 1
Leishmania major heat shock protein 83-1 0.0038 0.8441 0.729
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.8441 0.8441
Toxoplasma gondii NAC domain-containing protein 0.0041 1 1
Trypanosoma brucei transcription factor BTF3, putative 0.0041 1 1
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.8441 0.8441
Trichomonas vaginalis heat shock protein, putative 0.003 0.4245 0.3957
Echinococcus multilocularis heat shock protein 0.0038 0.8441 0.729
Trichomonas vaginalis heat shock protein, putative 0.003 0.4245 0.3957
Trichomonas vaginalis conserved hypothetical protein 0.0041 1 1
Leishmania major heat shock protein 83-1 0.0038 0.8441 0.729
Plasmodium falciparum basic transcription factor 3b, putative 0.0041 1 1
Leishmania major heat shock protein 83-1 0.0038 0.8441 0.729
Plasmodium falciparum heat shock protein 90 0.0038 0.8441 0.8363
Entamoeba histolytica hypothetical protein 0.0041 1 1
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.4245 0.4245
Leishmania major heat shock protein 83-1 0.0038 0.8441 0.729
Trypanosoma cruzi heat shock protein 90, putative 0.003 0.4245 0.4245
Trichomonas vaginalis conserved hypothetical protein 0.0041 1 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.003 0.4245 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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