Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | netrin receptor unc 5 | 0.0104 | 0.0427 | 0.0427 |
Schistosoma mansoni | jun-related protein | 0.0518 | 0.4081 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0432 | 0.0867 |
Brugia malayi | Death domain containing protein | 0.0104 | 0.0427 | 0.0832 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.0427 | 0.1047 |
Echinococcus granulosus | jun protein | 0.0638 | 0.5135 | 0.5135 |
Schistosoma mansoni | hypothetical protein | 0.0518 | 0.4081 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.0638 | 0.5135 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0638 | 0.5135 | 0.5135 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.119 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0044 | 0.0088 |
Schistosoma mansoni | netrin receptor unc5 | 0.0104 | 0.0427 | 0.1047 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0638 | 0.5135 | 0.5135 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0104 | 0.0427 | 0.0427 |
Echinococcus granulosus | Ankyrin | 0.0104 | 0.0432 | 0.0432 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0104 | 0.0427 | 0.1047 |
Echinococcus multilocularis | jun protein | 0.0638 | 0.5135 | 0.5135 |
Onchocerca volvulus | 0.0501 | 0.3927 | 1 | |
Echinococcus granulosus | death domain containing protein | 0.0104 | 0.0427 | 0.0427 |
Brugia malayi | Uncoordinated protein 44 | 0.0104 | 0.0427 | 0.0832 |
Brugia malayi | hypothetical protein | 0.0501 | 0.3927 | 0.7649 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0104 | 0.0427 | 0.0427 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0104 | 0.0427 | 0.0427 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0104 | 0.0432 | 0.1059 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0044 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0044 | 0.0088 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0104 | 0.0427 | 0.0858 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0044 | 0.0085 |
Echinococcus multilocularis | Ankyrin | 0.0104 | 0.0432 | 0.0432 |
Loa Loa (eye worm) | hypothetical protein | 0.062 | 0.498 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0104 | 0.0427 | 0.0832 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0104 | 0.0427 | 0.0832 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0427 | 0.0858 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.5119 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.8584 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.