Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0072 | 0.0773 | 0.5 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0072 | 0.0773 | 0.0504 |
Brugia malayi | MH2 domain containing protein | 0.0109 | 0.1394 | 0.5746 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0047 | 0.0367 | 0.4744 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0072 | 0.0773 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0045 | 0.0329 | 0.0237 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0109 | 0.1394 | 0.5746 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0047 | 0.0367 | 0.5 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0072 | 0.0773 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0072 | 0.0773 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0072 | 0.0773 | 1 |
Brugia malayi | Hint module family protein | 0.0159 | 0.2216 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0072 | 0.0773 | 0.0504 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0047 | 0.0367 | 0.0086 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0047 | 0.0367 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0072 | 0.0773 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0773 | 0.2533 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.2216 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0072 | 0.0773 | 0.5 |
Echinococcus multilocularis | hedgehog | 0.0587 | 0.9248 | 0.9227 |
Brugia malayi | Hint module family protein | 0.0159 | 0.2216 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.2216 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0632 | 1 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.0072 | 0.0773 | 0.2533 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0072 | 0.0773 | 0.5 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0072 | 0.0773 | 0.0504 |
Echinococcus granulosus | Desert hedgehog protein | 0.0587 | 0.9248 | 0.9227 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0072 | 0.0773 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0045 | 0.0329 | 0.0237 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0047 | 0.0367 | 0.0086 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0632 | 1 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0072 | 0.0773 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0109 | 0.1394 | 0.5746 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0072 | 0.0773 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0427 | 0.6626 | 0.6528 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.