TDR Targets

Basic information

Technical information

TDR Targets ID: 847197
Name: N-(5-chloro-2-methylphenyl)-1-(4-ethylphenyl) -5-methyltriazole-4-carboxamide
MW: 354.833 | Formula: C19H19ClN4O
H donors: 1 H acceptors: 3 LogP: 4.71 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccc(cc1)n1nnc(c1C)C(=O)Nc1cc(Cl)ccc1C
InChi: 1S/C19H19ClN4O/c1-4-14-6-9-16(10-7-14)24-13(3)18(22-23-24)19(25)21-17-11-15(20)8-5-12(17)2/h5-11H,4H2,1-3H3,(H,21,25)
InChiKey: UAYIPRVAOJJDKB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(5-chloro-2-methyl-phenyl)-1-(4-ethylphenyl)-5-methyl-triazole-4-carboxamide
N-(5-chloro-2-methylphenyl)-1-(4-ethylphenyl)-5-methyl-4-triazolecarboxamide
N-(5-chloro-2-methyl-phenyl)-1-(4-ethylphenyl)-5-methyl-1,2,3-triazole-4-carboxamide
ZINC02713343

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0049	0.1506	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0064
Echinococcus multilocularis	cathepsin b	0.0142	0.5874	0.7179
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0414	0.243
Onchocerca volvulus		0.0026	0.0414	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0414	0.243
Giardia lamblia	Cathepsin B precursor	0.0049	0.1506	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0414	0.243
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0414	1
Echinococcus granulosus	cathepsin b	0.0142	0.5874	0.7179
Brugia malayi	cathepsin B-like cysteine proteinase	0.0142	0.5874	0.5874
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0414	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.019	0.8182	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.5874	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0049	0.1506	0.2482
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.5874	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.019	0.8182	1
Loa Loa (eye worm)	fibroinase	0.0026	0.0414	0.0414
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0414	0.0414
Echinococcus granulosus	cathepsin l1	0.0026	0.0414	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0228	1	1
Onchocerca volvulus		0.0026	0.0414	1
Giardia lamblia	Cathepsin B precursor	0.0049	0.1506	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0414	0.243
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.1818	0.1818
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0414	0.243
Echinococcus multilocularis	cathepsin b	0.0142	0.5874	0.7179
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0414	0.0414
Brugia malayi	cathepsin L-like precursor	0.0019	0.0064	0.0064
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.0414	0.0506
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0977	0.0977
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0026	0.0414	0.0506
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0414	0.243
Schistosoma mansoni	hypothetical protein	0.0038	0.0977	0.1663
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0414	0.0603
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0026	0.0414	0.0414
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0064	0.0064
Toxoplasma gondii	cathepsin B	0.0049	0.1506	1
Onchocerca volvulus		0.0026	0.0414	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0414	0.243
Trypanosoma cruzi	cruzipain precursor, putative	0.0026	0.0414	0.0603
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0414	0.0414
Onchocerca volvulus		0.0026	0.0414	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.0414	0.0506
Loa Loa (eye worm)	cathepsin B	0.0049	0.1506	0.1506
Loa Loa (eye worm)	cysteine protease	0.0026	0.0414	0.0414
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0414	0.0414
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0414	1
Onchocerca volvulus		0.0026	0.0414	1
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0064	0.0064
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0026	0.0414	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0414	0.0603
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0414	0.243
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0414	0.0414
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0414	0.243
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0064
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.0414	0.0506
Echinococcus granulosus	cathepsin b	0.0142	0.5874	0.7179
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0414	0.243
Onchocerca volvulus		0.0026	0.0414	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0414	0.243
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0414	0.0414
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0026	0.0414	0.0506
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0414	0.243
Plasmodium vivax	vivapain-2	0.0026	0.0414	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0064
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0064	0.0108
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0026	0.0414	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0414	0.0603
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0049	0.1506	0.2563
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0414	0.243
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0414	1
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0414	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0142	0.5874	0.5874
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0414	0.243
Plasmodium vivax	vivapain-2	0.0026	0.0414	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0977	0.0977
Onchocerca volvulus		0.0026	0.0414	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0414	0.243
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0414	0.0705
Echinococcus granulosus	cathepsin l1	0.0019	0.0064	0.0078
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0414	0.243
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0414	0.0705
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0414	0.0414
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0414	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0414	0.243
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0414	0.243
Loa Loa (eye worm)	ctsf protein	0.0026	0.0414	0.0414
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0026	0.0414	0.0414
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0414	0.0603
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0019	0.0064	0.0064
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0142	0.5874	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0026	0.0414	0.5
Echinococcus multilocularis	cysteine protease	0.0026	0.0414	0.0506
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0414	0.243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0414	0.243
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0414	0.243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0414	0.243
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0142	0.5874	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0414	0.243
Giardia lamblia	Cathepsin B precursor	0.0049	0.1506	0.5
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.1818	0.1818
Echinococcus multilocularis	cysteine protease	0.0026	0.0414	0.0506
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0414	0.243
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.0414	0.0506
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0049	0.1506	1
Onchocerca volvulus	Cathepsin F homolog	0.0026	0.0414	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0414	0.243
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.5874	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0049	0.1506	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 847197