Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0235 | 0.0399 | 0.0241 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0235 | 0.0399 | 0.0241 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0197 | 0.0161 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0398 | 0.1411 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0398 | 0.1411 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0554 | 0.2375 | 0.225 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0235 | 0.0399 | 0.0241 |
Echinococcus granulosus | glutamate receptor NMDA | 0.123 | 0.6566 | 0.651 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0197 | 0.0161 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0235 | 0.0399 | 0.0241 |
Chlamydia trachomatis | glutamine binding protein | 0.0398 | 0.1411 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.123 | 0.6566 | 0.651 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.1784 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0184 | 0.0081 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0235 | 0.0399 | 0.0241 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.1309 | 0.706 | 0.7012 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0398 | 0.1411 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0235 | 0.0399 | 0.0241 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0235 | 0.0399 | 0.0241 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0235 | 0.0399 | 0.0241 |
Echinococcus granulosus | nmda type glutamate receptor | 0.1309 | 0.706 | 0.7012 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0398 | 0.1411 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0235 | 0.0399 | 0.0241 |
Schistosoma mansoni | glutamate receptor NMDA | 0.1465 | 0.8024 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0235 | 0.0399 | 0.0241 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0398 | 0.1411 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0184 | 0.0081 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.