Detailed information for compound 863253

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 346.383 | Formula: C20H18N4O2
  • H donors: 2 H acceptors: 4 LogP: 3.3 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccccc1NC(=O)Cn1ncc2c(c1O)nc1c2cccc1
  • InChi: 1S/C20H18N4O2/c1-2-13-7-3-5-9-16(13)22-18(25)12-24-20(26)19-15(11-21-24)14-8-4-6-10-17(14)23-19/h3-11,26H,2,12H2,1H3,(H,22,25)
  • InChiKey: URMXTYWXGHBZEB-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0125 0.1555 0.1092
Loa Loa (eye worm) matrixin family protein 0.0303 0.6098 0.6809
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0111 0.1181 0.1319
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0152 0.2253 0.1379
Onchocerca volvulus 0.0178 0.2894 0.3431
Loa Loa (eye worm) hypothetical protein 0.0414 0.8955 1
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0173 0.278 0.1813
Brugia malayi ADAMTS-like protease 0.0127 0.1603 0.0543
Brugia malayi ADAM-TS Spacer 1 family protein 0.0414 0.8955 1
Brugia malayi Matrixin family protein 0.0125 0.1555 0.048
Loa Loa (eye worm) hypothetical protein 0.0125 0.1555 0.1736
Echinococcus granulosus adam 0.0119 0.139 0.0237
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0103 0.0995 0.5
Schistosoma mansoni hypothetical protein 0.0178 0.2894 1
Mycobacterium ulcerans hydrolase 0.0152 0.2253 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0121 0.1441 0.0338
Loa Loa (eye worm) hypothetical protein 0.0131 0.1698 0.1897
Onchocerca volvulus Papilin homolog 0.0131 0.1698 0.0369
Loa Loa (eye worm) matrix metalloproteinase 0.0125 0.1555 0.1736
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0152 0.2253 0.5
Loa Loa (eye worm) hypothetical protein 0.0152 0.2253 0.2516
Brugia malayi Matrixin family protein 0.0303 0.6098 0.6324
Echinococcus multilocularis adam 0.0119 0.139 0.0237
Onchocerca volvulus Matrix metalloproteinase homolog 0.0278 0.5457 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.1555 0.1736
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0103 0.0995 0.5
Brugia malayi angiogenesis inhibito 0.0127 0.1603 0.0543
Brugia malayi Matrixin family protein 0.0125 0.1555 0.048
Brugia malayi hypothetical protein 0.0119 0.139 0.0269
Onchocerca volvulus Matrilysin homolog 0.0278 0.5457 1
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0455 1 1
Brugia malayi Hemopexin family protein 0.0178 0.2894 0.2203
Brugia malayi Matrixin family protein 0.0125 0.1555 0.048
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0173 0.278 0.1813
Mycobacterium leprae PROBABLE HYDROLASE 0.0152 0.2253 0.5
Loa Loa (eye worm) hypothetical protein 0.0125 0.1555 0.1736
Loa Loa (eye worm) matrixin family protein 0.0278 0.5457 0.6094
Loa Loa (eye worm) hypothetical protein 0.0096 0.0807 0.0901
Brugia malayi Matrixin family protein 0.0125 0.1555 0.048
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0173 0.278 0.9245
Loa Loa (eye worm) hypothetical protein 0.0119 0.139 0.1553
Schistosoma mansoni voltage-gated potassium channel 0.0121 0.1441 0.0338

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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