Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0125 | 0.1555 | 0.1092 |
Loa Loa (eye worm) | matrixin family protein | 0.0303 | 0.6098 | 0.6809 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0111 | 0.1181 | 0.1319 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0152 | 0.2253 | 0.1379 |
Onchocerca volvulus | 0.0178 | 0.2894 | 0.3431 | |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.8955 | 1 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0173 | 0.278 | 0.1813 |
Brugia malayi | ADAMTS-like protease | 0.0127 | 0.1603 | 0.0543 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0414 | 0.8955 | 1 |
Brugia malayi | Matrixin family protein | 0.0125 | 0.1555 | 0.048 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.1555 | 0.1736 |
Echinococcus granulosus | adam | 0.0119 | 0.139 | 0.0237 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0103 | 0.0995 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.2894 | 1 |
Mycobacterium ulcerans | hydrolase | 0.0152 | 0.2253 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0121 | 0.1441 | 0.0338 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.1698 | 0.1897 |
Onchocerca volvulus | Papilin homolog | 0.0131 | 0.1698 | 0.0369 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0125 | 0.1555 | 0.1736 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0152 | 0.2253 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.2253 | 0.2516 |
Brugia malayi | Matrixin family protein | 0.0303 | 0.6098 | 0.6324 |
Echinococcus multilocularis | adam | 0.0119 | 0.139 | 0.0237 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0278 | 0.5457 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.1555 | 0.1736 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0103 | 0.0995 | 0.5 |
Brugia malayi | angiogenesis inhibito | 0.0127 | 0.1603 | 0.0543 |
Brugia malayi | Matrixin family protein | 0.0125 | 0.1555 | 0.048 |
Brugia malayi | hypothetical protein | 0.0119 | 0.139 | 0.0269 |
Onchocerca volvulus | Matrilysin homolog | 0.0278 | 0.5457 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0455 | 1 | 1 |
Brugia malayi | Hemopexin family protein | 0.0178 | 0.2894 | 0.2203 |
Brugia malayi | Matrixin family protein | 0.0125 | 0.1555 | 0.048 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0173 | 0.278 | 0.1813 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0152 | 0.2253 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.1555 | 0.1736 |
Loa Loa (eye worm) | matrixin family protein | 0.0278 | 0.5457 | 0.6094 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0807 | 0.0901 |
Brugia malayi | Matrixin family protein | 0.0125 | 0.1555 | 0.048 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0173 | 0.278 | 0.9245 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.139 | 0.1553 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0121 | 0.1441 | 0.0338 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.