Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trichomonas vaginalis | set domain proteins, putative | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Onchocerca volvulus | Get druggable targets OG5_131470 | All targets in OG5_131470 | |
Brugia malayi | Pre-SET motif family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hexokinase | 0.0571 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0571 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0571 | 1 | 1 |
Onchocerca volvulus | 0.0359 | 0.5984 | 0.2539 | |
Entamoeba histolytica | hexokinase 1 | 0.0571 | 1 | 0.5 |
Onchocerca volvulus | 0.0571 | 1 | 1 | |
Trypanosoma cruzi | hexokinase, putative | 0.0571 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.265 | 0.265 |
Loa Loa (eye worm) | hypothetical protein | 0.039 | 0.6574 | 0.6574 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.3963 | 0.3963 |
Brugia malayi | Hexokinase family protein | 0.0359 | 0.5984 | 0.5984 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0359 | 0.0359 |
Echinococcus multilocularis | hexokinase | 0.0571 | 1 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.0571 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0177 | 0.2558 | 0.2558 |
Trypanosoma brucei | hexokinase, putative | 0.0571 | 1 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0571 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0571 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0177 | 0.2558 | 0.2558 |
Onchocerca volvulus | 0.0571 | 1 | 1 | |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.4618 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0359 | 0.0359 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0359 | 0.0359 |
Echinococcus granulosus | hexokinase | 0.0571 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0571 | 1 | 0.5 |
Onchocerca volvulus | 0.0571 | 1 | 1 | |
Schistosoma mansoni | hexokinase | 0.0571 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0571 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0571 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0571 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0571 | 1 | 0.5 |
Onchocerca volvulus | Hexokinase homolog | 0.0359 | 0.5984 | 0.2539 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.265 | 0.265 |
Entamoeba histolytica | hexokinase 2 | 0.0571 | 1 | 0.5 |
Brugia malayi | hexokinase type II | 0.0182 | 0.265 | 0.265 |
Trypanosoma brucei | hexokinase | 0.0571 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0571 | 1 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.3963 | 0.3963 |
Treponema pallidum | hexokinase (hxk) | 0.0571 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0571 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0571 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0571 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0571 | 1 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0359 | 0.0359 |
Loa Loa (eye worm) | hexokinase | 0.0359 | 0.5984 | 0.5984 |
Brugia malayi | Hexokinase family protein | 0.0571 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.