Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0391 | 1 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0391 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0391 | 1 | 0.5 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0009 | 0.0069 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.4395 | 1 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0188 | 0.4723 | 1 |
Schistosoma mansoni | regulator of G protein signaling | 0.0009 | 0.0069 | 0.0157 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1061 | 0.2414 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0149 | 0.371 | 1 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0009 | 0.0069 | 0.0157 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0009 | 0.0069 | 0.0157 |
Mycobacterium ulcerans | peptide deformylase | 0.0391 | 1 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0009 | 0.0069 | 0.0157 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.1061 | 0.2246 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0069 | 0.0146 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0069 | 0.0146 |
Trichomonas vaginalis | ras GTP exchange factor, son of sevenless, putative | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1061 | 0.2414 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0009 | 0.0069 | 0.0146 |
Toxoplasma gondii | hypothetical protein | 0.0391 | 1 | 1 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0009 | 0.0069 | 0.0146 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0149 | 0.371 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | dep domain containing protein | 0.0009 | 0.0069 | 0.0157 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.4723 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1061 | 0.2414 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0149 | 0.371 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.0391 | 1 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.1061 | 0.2246 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0009 | 0.0069 | 0.0157 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0149 | 0.371 | 1 |
Schistosoma mansoni | dishevelled | 0.0009 | 0.0069 | 0.0157 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0069 | 0.0146 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0009 | 0.0069 | 0.0157 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0009 | 0.0069 | 0.0157 |
Plasmodium vivax | peptide deformylase, putative | 0.0391 | 1 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.4395 | 1 |
Onchocerca volvulus | 0.0009 | 0.0069 | 0.0146 | |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0009 | 0.0069 | 0.0146 |
Entamoeba histolytica | hypothetical protein | 0.0007 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0149 | 0.371 | 0.5 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0009 | 0.0069 | 0.0157 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Brugia malayi | N-terminal motif family protein | 0.0188 | 0.4723 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1061 | 0.2414 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0009 | 0.0069 | 0.0157 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0009 | 0.0069 | 0.0157 |
Plasmodium falciparum | peptide deformylase | 0.0391 | 1 | 0.5 |
Brugia malayi | DIX domain containing protein | 0.0009 | 0.0069 | 0.0146 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1061 | 0.2414 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0009 | 0.0069 | 0.0157 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0149 | 0.371 | 1 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0149 | 0.371 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | dishevelled | 0.0009 | 0.0069 | 0.0157 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0009 | 0.0069 | 0.0157 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1061 | 0.2414 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0009 | 0.0069 | 0.0146 |
Trichomonas vaginalis | guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0009 | 0.0069 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0069 | 0.0146 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1061 | 0.2414 |
Echinococcus granulosus | geminin | 0.0175 | 0.4395 | 1 |
Echinococcus multilocularis | geminin | 0.0175 | 0.4395 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0069 | 0.0146 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0009 | 0.0069 | 0.0157 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.