Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | oxidoreductase-like protein | 0.0011 | 0.0137 | 0.0138 |
Mycobacterium leprae | POSSIBLE OXIDOREDUCTASE | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0008 | 0 | 0.5 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] reductase, putative | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | dihydropteridine reductase | 0.0008 | 0 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0008 | 0 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0008 | 0 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0011 | 0.0137 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0008 | 0 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0008 | 0 | 0.5 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0008 | 0 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0011 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0008 | 0 | 0.5 |
Chlamydia trachomatis | oxoacy-ACP reductase | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0008 | 0 | 0.5 |
Mycobacterium leprae | 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI | 0.0008 | 0 | 0.5 |
Onchocerca volvulus | 0.0011 | 0.0137 | 1 | |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0011 | 0.0137 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0011 | 0.0137 | 1 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0011 | 0.0137 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.0188 | 0.9863 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0008 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0008 | 0 | 0.5 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0011 | 0.0137 | 1 |
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0008 | 0 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0008 | 0 | 0.5 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0011 | 0.0137 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0011 | 0.0137 | 1 |
Wolbachia endosymbiont of Brugia malayi | Short-chain alcohol dehydrogenase family enzyme | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0008 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.