Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | matrixin family protein | 0.5522 | 0.2059 | 0.2761 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 1.2764 | 0.5192 | 0.5192 |
Loa Loa (eye worm) | hypothetical protein | 0.2955 | 0.0949 | 0.1248 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 1.1359 | 0.4584 | 0.4653 |
Loa Loa (eye worm) | hypothetical protein | 0.3032 | 0.0982 | 0.1293 |
Loa Loa (eye worm) | hypothetical protein | 0.249 | 0.0747 | 0.0974 |
Onchocerca volvulus | 0.332 | 0.1107 | 0.2374 | |
Mycobacterium ulcerans | hydrolase | 0.3032 | 0.0982 | 0.5 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.3032 | 0.0982 | 0.5 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0838 | 0.0033 | 0.0074 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.5522 | 0.2059 | 0.867 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 1.1115 | 0.4479 | 1 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 1.2764 | 0.5192 | 0.5269 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.249 | 0.0747 | 0.0974 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.2955 | 0.0949 | 0.0963 |
Brugia malayi | Matrixin family protein | 0.249 | 0.0747 | 0.1669 |
Loa Loa (eye worm) | hypothetical protein | 1.7802 | 0.7371 | 1 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.3032 | 0.0982 | 0.2193 |
Echinococcus multilocularis | adam 17 protease | 2.3538 | 0.9853 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.6275 | 0.2385 | 0.3205 |
Schistosoma mansoni | hypothetical protein | 0.332 | 0.1107 | 0.1123 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.9307 | 0.3697 | 0.3697 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.2474 | 0.074 | 0.0752 |
Brugia malayi | Matrixin family protein | 0.249 | 0.0747 | 0.1669 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 1.1359 | 0.4584 | 0.4653 |
Brugia malayi | Matrixin family protein | 0.6275 | 0.2385 | 0.5325 |
Brugia malayi | Matrixin family protein | 0.249 | 0.0747 | 0.1669 |
Brugia malayi | Matrixin family protein | 0.249 | 0.0747 | 0.1669 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.9307 | 0.3697 | 0.3752 |
Brugia malayi | Hemopexin family protein | 0.332 | 0.1107 | 0.2471 |
Onchocerca volvulus | Matrilysin homolog | 0.5987 | 0.226 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.249 | 0.0747 | 0.0974 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.3032 | 0.0982 | 0.5 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 2.3538 | 0.9853 | 1 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 1.1359 | 0.4584 | 0.4584 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.