Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | matrixin family protein | 0.0307 | 0.4537 | 0.6293 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0324 | 0.4997 | 0.5 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0169 | 0.0684 | 0.5 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0324 | 0.4997 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.0684 | 0.0949 |
Toxoplasma gondii | hypothetical protein | 0.024 | 0.2662 | 0.5 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0324 | 0.4997 | 0.6931 |
Brugia malayi | Matrixin family protein | 0.0335 | 0.5307 | 0.7361 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.0403 | 0.721 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0307 | 0.4537 | 1 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0403 | 0.721 | 1 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0324 | 0.4997 | 0.6931 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0324 | 0.4997 | 0.6155 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0324 | 0.4997 | 0.5134 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0504 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0307 | 0.4537 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0324 | 0.4997 | 0.5134 |
Echinococcus multilocularis | geranylgeranyl transferase type I beta subunit | 0.0403 | 0.721 | 0.4423 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0169 | 0.0684 | 0.0949 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0403 | 0.721 | 1 |
Entamoeba histolytica | geranylgeranyl transferase beta subunit | 0.0403 | 0.721 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0324 | 0.4997 | 0.5134 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.0403 | 0.721 | 1 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.0403 | 0.721 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0169 | 0.0684 | 0.5 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0324 | 0.4997 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0335 | 0.5307 | 0.7361 |
Echinococcus granulosus | geranylgeranyl transferase type I beta subunit | 0.0403 | 0.721 | 0.4423 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.4997 | 0.6931 |
Brugia malayi | Hemopexin family protein | 0.0196 | 0.1455 | 0.2018 |
Mycobacterium ulcerans | hydrolase | 0.0169 | 0.0684 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5805 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.