Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0104 | 0.217 | 0.217 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0104 | 0.217 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0428 | 1 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0428 | 1 | 0.5 |
Schistosoma mansoni | amidase | 0.0104 | 0.217 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0428 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.217 | 0.217 |
Trypanosoma brucei | lipase domain protein, putative | 0.0428 | 1 | 0.5 |
Loa Loa (eye worm) | lipase | 0.0428 | 1 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0428 | 1 | 1 |
Brugia malayi | amidase | 0.0104 | 0.217 | 0.217 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0428 | 1 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0104 | 0.217 | 0.217 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0428 | 1 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0104 | 0.217 | 0.217 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0104 | 0.217 | 0.217 |
Onchocerca volvulus | 0.0428 | 1 | 1 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0428 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0428 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.