Detailed information for compound 865841

Basic information

Technical information
  • TDR Targets ID: 865841
  • Name: N-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]-1 -pyridin-3-ylethanimine
  • MW: 344.453 | Formula: C22H24N4
  • H donors: 0 H acceptors: 1 LogP: 3.83 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=NN1CCN(CC1)Cc1cccc2c1cccc2)c1cccnc1
  • InChi: 1S/C22H24N4/c1-18(20-9-5-11-23-16-20)24-26-14-12-25(13-15-26)17-21-8-4-7-19-6-2-3-10-22(19)21/h2-11,16H,12-15,17H2,1H3/b24-18+
  • InChiKey: LNPOBRXJZYGQMS-HKOYGPOVSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • N-[4-(1-naphthylmethyl)piperazin-1-yl]-1-(3-pyridyl)ethanimine
  • N-[4-(1-naphthylmethyl)-1-piperazinyl]-1-(3-pyridyl)ethanimine
  • [4-(1-naphthylmethyl)piperazin-1-yl]-[1-(3-pyridyl)ethylidene]amine
  • (E)-[4-(1-naphthylmethyl)piperazin-1-yl]-[1-(3-pyridyl)ethylidene]amine
  • N-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]-1-pyridin-3-yl-ethanimine
  • BIM-0044007.P001
  • Oprea1_012100
  • CBMicro_043865
  • 4-(1-naphthylmethyl)-N-[1-(3-pyridinyl)ethylidene]-1-piperazinamine
  • MLS000684812
  • SMR000268111

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.0814 1
Trypanosoma cruzi Peptide deformylase 2, putative 0.0734 0.3672 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0 0.5
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0814 0.1939
Onchocerca volvulus 0.0114 0.0373 0.5
Echinococcus granulosus microtubule associated protein 2 0.0833 0.4201 1
Brugia malayi MH2 domain containing protein 0.0144 0.0535 0.6566
Leishmania major polypeptide deformylase-like protein, putative 0.0734 0.3672 1
Toxoplasma gondii hypothetical protein 0.1923 1 1
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0734 0.3672 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0 0.5
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0 0.5
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.1923 1 0.5
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0 0.5
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0 0.5
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0734 0.3672 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0 0.5
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.1923 1 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0 0.5
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.0814 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.0814 0.1939
Plasmodium falciparum peptide deformylase 0.1923 1 0.5
Treponema pallidum polypeptide deformylase (def) 0.1923 1 0.5
Schistosoma mansoni alpha-glucosidase 0.0169 0.0669 0.1592
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0814 0.1939
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.1923 1 0.5
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0 0.5
Plasmodium vivax peptide deformylase, putative 0.1923 1 0.5
Trypanosoma brucei Polypeptide deformylase 1 0.0734 0.3672 1
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.4201 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0535 0.6566
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0 0.5
Schistosoma mansoni alpha-glucosidase 0.0169 0.0669 0.1592
Trypanosoma cruzi Peptide deformylase 2, putative 0.0734 0.3672 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0535 0.6566
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.4201 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0 0.5
Mycobacterium ulcerans peptide deformylase 0.1923 1 0.5
Trypanosoma brucei Peptide deformylase 2 0.0734 0.3672 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.