Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0076 | 0.0633 | 0.0633 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.0458 | 0.0663 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0458 | 0.0663 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.0458 | 0.0458 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.1298 | 0.1298 |
Entamoeba histolytica | hypothetical protein | 0.0108 | 0.1102 | 0.5 |
Echinococcus multilocularis | jun protein | 0.026 | 0.3295 | 0.4773 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0458 | 0.0663 |
Entamoeba histolytica | hypothetical protein | 0.0108 | 0.1102 | 0.5 |
Brugia malayi | bZIP transcription factor family protein | 0.026 | 0.3295 | 0.3295 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.1298 | 0.1298 |
Schistosoma mansoni | hypothetical protein | 0.0108 | 0.1102 | 0.1596 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0076 | 0.0633 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0458 | 0.0663 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0187 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0966 | 0.0966 |
Echinococcus granulosus | geminin | 0.051 | 0.6904 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0108 | 0.1102 | 0.1596 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0076 | 0.0633 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0458 | 0.0663 |
Brugia malayi | RNA binding protein | 0.0064 | 0.0458 | 0.0458 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0076 | 0.0633 | 1 |
Echinococcus multilocularis | geminin | 0.051 | 0.6904 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0076 | 0.0633 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0187 | 0.0271 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.0458 | 0.0458 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.026 | 0.3295 | 0.4773 |
Brugia malayi | hypothetical protein | 0.0204 | 0.2488 | 0.2488 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.1298 | 0.1298 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0108 | 0.1102 | 0.1596 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.026 | 0.3295 | 0.4773 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.0458 | 0.0458 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0725 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0187 | 0.0271 |
Schistosoma mansoni | hypothetical protein | 0.051 | 0.6904 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.3192 | 0.3192 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0187 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0633 | 0.0633 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0098 | 0.095 | 0.095 |
Schistosoma mansoni | jun-related protein | 0.0212 | 0.2591 | 0.3753 |
Entamoeba histolytica | hypothetical protein | 0.0108 | 0.1102 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.0458 | 0.0663 |
Brugia malayi | hypothetical protein | 0.0049 | 0.0245 | 0.0245 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0108 | 0.1102 | 0.1102 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0187 | 0.0271 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0076 | 0.0633 | 1 |
Onchocerca volvulus | 0.0725 | 1 | 1 | |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0076 | 0.0633 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0029 | 0.0042 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0458 | 0.0663 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0108 | 0.1102 | 0.1596 |
Entamoeba histolytica | hypothetical protein | 0.0108 | 0.1102 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0076 | 0.0633 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0108 | 0.1102 | 0.1596 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0187 | 0.0271 |
Echinococcus granulosus | jun protein | 0.026 | 0.3295 | 0.4773 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.0458 | 0.0458 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0034 | 0.0029 | 0.0042 |
Brugia malayi | hypothetical protein | 0.0108 | 0.1102 | 0.1102 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.0458 | 0.0458 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0108 | 0.1102 | 0.1596 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0034 | 0.0029 | 0.0042 |
Schistosoma mansoni | hypothetical protein | 0.0212 | 0.2591 | 0.3753 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0187 | 0.0271 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0187 | 0.0271 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0187 | 0.0271 |
Leishmania major | hypothetical protein, conserved | 0.0076 | 0.0633 | 1 |
Schistosoma mansoni | hypothetical protein | 0.051 | 0.6904 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.