Detailed information for compound 867557

Basic information

Technical information
  • TDR Targets ID: 867557
  • Name: 4-butylamino-1H-quinazoline-2-thione
  • MW: 233.333 | Formula: C12H15N3S
  • H donors: 1 H acceptors: 2 LogP: 3.59 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCNc1nc(S)nc2c1cccc2
  • InChi: 1S/C12H15N3S/c1-2-3-8-13-11-9-6-4-5-7-10(9)14-12(16)15-11/h4-7H,2-3,8H2,1H3,(H2,13,14,15,16)
  • InChiKey: FUXBJYOLVRMPLX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0458 0.0663
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.1102 0.1596
Schistosoma mansoni hypothetical protein 0.0212 0.2591 0.3753
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0187 0.0187
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0633 1
Entamoeba histolytica hypothetical protein 0.0108 0.1102 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0633 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0187 0.0271
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0458 0.0458
Echinococcus granulosus geminin 0.051 0.6904 1
Brugia malayi TAR-binding protein 0.0064 0.0458 0.0458
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0187 0.0271
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0633 1
Echinococcus granulosus jun protein 0.026 0.3295 0.4773
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.1298 0.1298
Loa Loa (eye worm) pax transcription factor protein 2 0.0725 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.026 0.3295 0.4773
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0187 0.0271
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0108 0.1102 0.1596
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0187 0.0271
Brugia malayi MH2 domain containing protein 0.0122 0.1298 0.1298
Schistosoma mansoni hypothetical protein 0.051 0.6904 1
Echinococcus multilocularis jun protein 0.026 0.3295 0.4773
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0187 0.0271
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0458 0.0663
Echinococcus granulosus tar DNA binding protein 0.0064 0.0458 0.0663
Entamoeba histolytica hypothetical protein 0.0108 0.1102 0.5
Brugia malayi bZIP transcription factor family protein 0.026 0.3295 0.3295
Brugia malayi Steroid receptor seven-up type 2 0.0108 0.1102 0.1102
Loa Loa (eye worm) hypothetical protein 0.0253 0.3192 0.3192
Entamoeba histolytica hypothetical protein 0.0108 0.1102 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0187 0.0271
Schistosoma mansoni hypothetical protein 0.051 0.6904 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.1298 0.1298
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0458 0.0663
Schistosoma mansoni hypothetical protein 0.0034 0.0029 0.0042
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0458 0.0663
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0187 0.0187
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.026 0.3295 0.4773
Brugia malayi hypothetical protein 0.0049 0.0245 0.0245
Brugia malayi hypothetical protein 0.0108 0.1102 0.1102
Schistosoma mansoni hypothetical protein 0.0108 0.1102 0.1596
Leishmania major hypothetical protein, conserved 0.0076 0.0633 1
Brugia malayi RNA binding protein 0.0064 0.0458 0.0458
Echinococcus multilocularis geminin 0.051 0.6904 1
Brugia malayi hypothetical protein 0.0204 0.2488 0.2488
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.1102 0.1596
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0633 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0187 0.0271
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0108 0.1102 0.1596
Brugia malayi hypothetical protein 0.0076 0.0633 0.0633
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.1102 0.1596
Onchocerca volvulus 0.0725 1 1
Loa Loa (eye worm) nuclear hormone receptor 0.0098 0.095 0.095
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0633 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0029 0.0042
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0458 0.0458
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0458 0.0458
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0029 0.0042
Loa Loa (eye worm) RNA binding protein 0.0064 0.0458 0.0458
Entamoeba histolytica hypothetical protein 0.0108 0.1102 0.5
Schistosoma mansoni jun-related protein 0.0212 0.2591 0.3753
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0633 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0633 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0458 0.0663
Loa Loa (eye worm) hypothetical protein 0.0099 0.0966 0.0966
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0076 0.0633 0.0633
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0458 0.0663

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.