TDR Targets

Basic information

Technical information

TDR Targets ID: 867708
Name: 4,5-dimethyl-3-oxido-2-thiophen-2-yl-1,3-oxaz ol-3-ium
MW: 195.238 | Formula: C9H9NO2S
H donors: 0 H acceptors: 1 LogP: 2.18 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Cc1c(C)oc([n+]1[O-])c1cccs1
InChi: 1S/C9H9NO2S/c1-6-7(2)12-9(10(6)11)8-4-3-5-13-8/h3-5H,1-2H3
InChiKey: ZGFQXKNJHVDQDT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4,5-dimethyl-3-oxido-2-(2-thienyl)oxazol-3-ium
EU-0062831

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.001	0.0027	0.004
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0239	0.0212
Trypanosoma brucei	hypothetical protein, conserved	0.0126	0.2748	0.2728
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.001	0.0027	0.004
Brugia malayi	hypothetical protein	0.001	0.0027	0.0069
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.001	0.0027	0.004
Schistosoma mansoni	hypothetical protein	0.001	0.0027	0.0027
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0102	0.0074
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0239	0.0239
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.001	0.0027	0.004
Brugia malayi	Pao retrotransposon peptidase family protein	0.001	0.0027	0.0069
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0239	0.5
Trichomonas vaginalis	ran, putative	0.0021	0.0283	0.1028
Brugia malayi	Pao retrotransposon peptidase family protein	0.001	0.0027	0.0069
Brugia malayi	Pao retrotransposon peptidase family protein	0.001	0.0027	0.0069
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0458	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0239	0.0239
Brugia malayi	Pao retrotransposon peptidase family protein	0.001	0.0027	0.0069
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0283	0.0413
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0239	0.0348
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.001	0.0027	0.004
Brugia malayi	Zinc knuckle family protein	0.001	0.0027	0.0069
Echinococcus granulosus	ribonuclease H1	0.0116	0.2517	0.3669
Entamoeba histolytica	Ran family GTPase	0.0021	0.0283	0.471
Brugia malayi	reverse transcriptase	0.001	0.0027	0.0069
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0283	0.1125
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0239	0.085
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0458	0.0667
Brugia malayi	RNase H family protein	0.0116	0.2517	0.639
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0458	0.0432
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0239	0.0212
Onchocerca volvulus	Telomerase reverse transcriptase homolog	0.001	0.0027	0.0069
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0239	0.0348
Treponema pallidum	ribonuclease H (rnhA)	0.0116	0.2517	0.5
Echinococcus granulosus	RNA directed DNA polymerase	0.001	0.0027	0.004
Schistosoma mansoni	phosphoglucomutase	0.0116	0.2517	0.2517
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0239	0.0348
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0239	1
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.001	0.0027	0.004
Toxoplasma gondii	ribonuclease HI protein	0.0116	0.2517	1
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0239	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0239	0.0212
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0239	0.0348
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0239	0.0212
Echinococcus multilocularis	RNA directed DNA polymerase	0.001	0.0027	0.004
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0283	0.0413
Brugia malayi	hypothetical protein	0.001	0.0027	0.0069
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0283	0.1028
Trypanosoma brucei	ribonuclease H1	0.0116	0.2517	0.2497
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0283	0.1028
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0458	0.0667
Echinococcus granulosus	dna polymerase eta	0.0019	0.0239	0.0348
Onchocerca volvulus		0.001	0.0027	0.0069
Brugia malayi	RNase H family protein	0.0116	0.2517	0.639
Brugia malayi	Pao retrotransposon peptidase family protein	0.001	0.0027	0.0069
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.001	0.0027	0.004
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0333	0.1227
Brugia malayi	reverse transcriptase	0.001	0.0027	0.0069
Trichomonas vaginalis	ribonuclease H1, putative	0.0116	0.2517	1
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0239	0.0212
Brugia malayi	Pao retrotransposon peptidase family protein	0.001	0.0027	0.0069
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0458	0.0432
Schistosoma mansoni	phosphoglucomutase	0.0116	0.2517	0.2517
Trypanosoma brucei	unspecified product	0.0019	0.0239	0.0212
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0458	0.1819
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0239	0.085
Brugia malayi	Pao retrotransposon peptidase family protein	0.001	0.0027	0.0069
Onchocerca volvulus		0.001	0.0027	0.0069
Schistosoma mansoni	scy1(yeast) protein kinase-like	0.001	0.0027	0.0027
Brugia malayi	N-terminal motif family protein	0.0177	0.3939	1
Brugia malayi	Pao retrotransposon peptidase family protein	0.001	0.0027	0.0069
Giardia lamblia	Ribonuclease H	0.0116	0.2517	1
Leishmania major	GTP-binding protein, putative	0.0021	0.0283	0.0194
Schistosoma mansoni	protein kinase	0.001	0.0027	0.0027
Trypanosoma brucei	unspecified product	0.0126	0.2748	0.2728
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0239	0.085
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0239	0.0212
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.001	0.0027	0.004
Trypanosoma brucei	unspecified product	0.0013	0.0102	0.0074
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0283	0.0257
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0283	0.1028
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0126	0.2748	0.2728
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.001	0.0027	0.004
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0239	0.0348
Brugia malayi	Pao retrotransposon peptidase family protein	0.001	0.0027	0.0069
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0239	0.0212
Trypanosoma cruzi	ribonuclease H1, putative	0.0116	0.2517	1
Brugia malayi	Pao retrotransposon peptidase family protein	0.001	0.0027	0.0069
Brugia malayi	Pao retrotransposon peptidase family protein	0.001	0.0027	0.0069
Schistosoma mansoni	serine/threonine protein kinase	0.001	0.0027	0.0027
Trypanosoma brucei	ingi protein (ORF1)	0.0126	0.2748	0.2728
Echinococcus multilocularis	ribonuclease H1	0.0116	0.2517	0.3669
Brugia malayi	RNase H family protein	0.0116	0.2517	0.639
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0102	0.0074
Brugia malayi	hypothetical protein	0.001	0.0027	0.0069
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0283	0.0413
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0239	0.0239
Trypanosoma brucei	RNA helicase, putative	0.0436	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0239	0.0212
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0239	0.085
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0458	0.0667
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0283	0.0719
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0333	0.1227
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0333	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0177	0.3939	0.5742
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.001	0.0027	0.004
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.001	0.0027	0.004
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0239	0.5
Trypanosoma cruzi	ribonuclease H1, putative	0.0116	0.2517	1
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0333	0.1227
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0239	0.0212
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0239	0.0607
Leishmania major	ribonuclease H1, putative	0.0116	0.2517	1
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.001	0.0027	0.004
Schistosoma mansoni	hypothetical protein	0.0302	0.686	0.686
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0239	0.085
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0239	0.0212
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0239	0.0212
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0239	0.085
Echinococcus granulosus	KRAB A domain containing protein	0.001	0.0027	0.004
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0239	0.085
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0333	0.1227
Brugia malayi	Importin beta-1 subunit	0.0028	0.0458	0.1162
Brugia malayi	Pao retrotransposon peptidase family protein	0.001	0.0027	0.0069
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.001	0.0027	0.004
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0239	0.0348
Brugia malayi	Zinc knuckle family protein	0.001	0.0027	0.0069
Brugia malayi	Pao retrotransposon peptidase family protein	0.001	0.0027	0.0069
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0239	0.0212
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0239	0.0212
Brugia malayi	Pao retrotransposon peptidase family protein	0.001	0.0027	0.0069
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0116	0.2517	0.5
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.001	0.0027	0.004
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0102	0.0074
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0177	0.3939	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0239	0.0212
Echinococcus granulosus	snurportin 1	0.0302	0.686	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0302	0.686	1
Brugia malayi	reverse transcriptase	0.001	0.0027	0.0069
Schistosoma mansoni	ran	0.0021	0.0283	0.0283
Trypanosoma brucei	unspecified product	0.0013	0.0102	0.0074
Entamoeba histolytica	hypothetical protein	0.0023	0.0333	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0239	0.0607
Schistosoma mansoni	importin beta-1	0.0028	0.0458	0.0458
Plasmodium falciparum	importin beta, putative	0.0028	0.0458	1
Echinococcus multilocularis	snurportin 1	0.0302	0.686	1
Brugia malayi	hypothetical protein	0.001	0.0027	0.0069
Brugia malayi	RNA, U transporter 1	0.008	0.1678	0.426
Schistosoma mansoni	hypothetical protein	0.001	0.0027	0.0027
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0239	0.0348
Trypanosoma brucei	ingi protein (ORF1)	0.0126	0.2748	0.2728
Schistosoma mansoni	ran	0.0021	0.0283	0.0283
Onchocerca volvulus	Ribonuclease H1 homolog	0.0116	0.2517	0.639
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0239	0.085
Schistosoma mansoni	phosphoglucomutase	0.0116	0.2517	0.2517

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 867708