Detailed information for compound 867800

Basic information

Technical information
  • TDR Targets ID: 867800
  • Name: N-(3-fluorophenyl)-3-[(2-methoxyacetyl)amino] -1-benzofuran-2-carboxamide
  • MW: 342.321 | Formula: C18H15FN2O4
  • H donors: 2 H acceptors: 2 LogP: 3.21 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCC(=O)Nc1c(oc2c1cccc2)C(=O)Nc1cccc(c1)F
  • InChi: 1S/C18H15FN2O4/c1-24-10-15(22)21-16-13-7-2-3-8-14(13)25-17(16)18(23)20-12-6-4-5-11(19)9-12/h2-9H,10H2,1H3,(H,20,23)(H,21,22)
  • InChiKey: FXOFZSSXGDFXGW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-fluorophenyl)-3-[(2-methoxyacetyl)amino]benzofuran-2-carboxamide
  • N-(3-fluorophenyl)-3-[(2-methoxy-1-oxoethyl)amino]-2-benzofurancarboxamide
  • N-(3-fluorophenyl)-3-(2-methoxyethanoylamino)-1-benzofuran-2-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni serine/threonine protein kinase 0.0128 0.2248 0.2041
Loa Loa (eye worm) MIR domain-containing protein 0.0033 0.026 0.0391
Schistosoma mansoni ryanodine receptor related 0.0499 1 1
Trichomonas vaginalis AGC family protein kinase 0.0128 0.2248 1
Schistosoma mansoni hypothetical protein 0.0123 0.2135 0.1925
Brugia malayi cation channel family protein 0.0213 0.4024 0.4024
Loa Loa (eye worm) hypothetical protein 0.0315 0.6154 0.9267
Leishmania major protein kinase, putative 0.0128 0.2248 1
Giardia lamblia Aurora kinase 0.0128 0.2248 0.5
Schistosoma mansoni tyrosine kinase 0.0179 0.3307 0.3128
Echinococcus multilocularis ryanodine receptor 44f 0.0404 0.8013 1
Echinococcus granulosus epidermal growth factor receptor 0.0338 0.664 0.8229
Brugia malayi Furin-like cysteine rich region family protein 0.0338 0.664 0.664
Loa Loa (eye worm) AUR protein kinase 0.0128 0.2248 0.3385
Trichomonas vaginalis AGC family protein kinase 0.0128 0.2248 1
Toxoplasma gondii aurora kinase 0.0128 0.2248 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.0338 0.664 0.8229
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0153 0.2752 0.2559
Schistosoma mansoni tyrosine kinase 0.0109 0.1845 0.1628
Schistosoma mansoni tyrosine kinase 0.0183 0.338 0.3203
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0128 0.2248 0.2564
Echinococcus granulosus insulin receptor 0.0109 0.1845 0.2045
Loa Loa (eye worm) ryanodine receptor 0.0118 0.2024 0.3048
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0109 0.1845 0.2045
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.018 0.3324 1
Echinococcus granulosus epidermal growth factor receptor 0.0183 0.338 0.4024
Loa Loa (eye worm) hypothetical protein 0.0061 0.0832 0.1253
Brugia malayi serine/threonine protein kinase 6 0.0128 0.2248 0.2248
Schistosoma mansoni tyrosine kinase 0.0179 0.3307 0.3128
Schistosoma mansoni tyrosine kinase 0.0183 0.338 0.3203
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0128 0.2248 0.2564
Loa Loa (eye worm) TK/EGFR protein kinase 0.0338 0.664 1
Brugia malayi serine/threonine-protein kinase 6 0.0128 0.2248 0.2248
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0128 0.2248 1
Entamoeba histolytica protein kinase domain containing protein 0.0128 0.2248 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0109 0.1845 0.2779
Trichomonas vaginalis AGC family protein kinase 0.0128 0.2248 1
Schistosoma mansoni tyrosine kinase 0.0338 0.664 0.6551
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0183 0.338 0.4024
Onchocerca volvulus 0.0033 0.026 0.5
Brugia malayi MIR domain containing protein 0.0033 0.026 0.026
Entamoeba histolytica protein kinase, putative 0.0128 0.2248 1
Brugia malayi serine/threonine kinase 12 0.0128 0.2248 0.2248
Echinococcus multilocularis aurora kinase A 0.0128 0.2248 0.2564
Trichomonas vaginalis AGC family protein kinase 0.0128 0.2248 1
Entamoeba histolytica protein kinase , putative 0.0128 0.2248 1
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0061 0.0832 0.0588
Brugia malayi Protein kinase domain containing protein 0.0109 0.1845 0.1845
Loa Loa (eye worm) ryanodine receptor 0.0186 0.346 0.5211
Schistosoma mansoni tyrosine kinase 0.0179 0.3307 0.3128
Echinococcus multilocularis 0.0104 0.1742 0.1911
Echinococcus granulosus ryanodine receptor 44f 0.0404 0.8013 1
Loa Loa (eye worm) AUR protein kinase 0.0128 0.2248 0.3385
Schistosoma mansoni protein kinase 0.0128 0.2248 0.2041
Plasmodium falciparum serine/threonine protein kinase, putative 0.0128 0.2248 0.5
Echinococcus granulosus aurora kinase A 0.0128 0.2248 0.2564
Echinococcus multilocularis insulin receptor 0.0109 0.1845 0.2045
Echinococcus granulosus ryanodine receptor 44f 0.0315 0.6154 0.7602
Echinococcus multilocularis epidermal growth factor receptor 0.0183 0.338 0.4024
Echinococcus multilocularis ryanodine receptor 44f 0.0315 0.6154 0.7602
Loa Loa (eye worm) AUR protein kinase 0.0128 0.2248 0.3385
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0128 0.2248 0.5
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0109 0.1845 0.2045
Loa Loa (eye worm) hypothetical protein 0.0091 0.1465 0.2206
Schistosoma mansoni tyrosine kinase 0.0109 0.1845 0.1628
Schistosoma mansoni ryanodine receptor 1 skeletal muscle 0.0058 0.0766 0.0519
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0128 0.2248 1
Entamoeba histolytica protein kinase, putative 0.0128 0.2248 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1547 0.233
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.018 0.3324 1
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0128 0.2248 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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