Detailed information for compound 867915

Basic information

Technical information
  • TDR Targets ID: 867915
  • Name: N-(3-chloro-2-methylphenyl)-3-(2-oxo-1,3-benz othiazol-3-yl)propanamide
  • MW: 346.831 | Formula: C17H15ClN2O2S
  • H donors: 1 H acceptors: 2 LogP: 3.66 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1C)Cl)CCn1c(=O)sc2c1cccc2
  • InChi: 1S/C17H15ClN2O2S/c1-11-12(18)5-4-6-13(11)19-16(21)9-10-20-14-7-2-3-8-15(14)23-17(20)22/h2-8H,9-10H2,1H3,(H,19,21)
  • InChiKey: QCKQHMNGSDCFBR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-chloro-2-methyl-phenyl)-3-(2-oxo-1,3-benzothiazol-3-yl)propanamide
  • N-(3-chloro-2-methyl-phenyl)-3-(2-keto-1,3-benzothiazol-3-yl)propionamide
  • ZINC00246091
  • ST5129643

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0167 0.2293 1
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.021 0.5
Brugia malayi glutathione reductase 0.005 0.021 0.0294
Loa Loa (eye worm) hypothetical protein 0.0362 0.5765 0.8009
Schistosoma mansoni single-minded 0.0051 0.0235 0.0016
Leishmania major trypanothione reductase 0.005 0.021 0.5
Echinococcus granulosus histone lysine methyltransferase setb 0.0167 0.2293 1
Brugia malayi PAS domain containing protein 0.0051 0.0235 0.0329
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0167 0.2293 0.2435
Plasmodium falciparum thioredoxin reductase 0.005 0.021 0.5
Brugia malayi hypothetical protein 0.0171 0.2368 0.3313
Plasmodium vivax SET domain protein, putative 0.0167 0.2293 1
Brugia malayi Pre-SET motif family protein 0.0167 0.2293 0.3209
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.021 0.5
Trichomonas vaginalis set domain proteins, putative 0.06 1 0.5
Trypanosoma brucei trypanothione reductase 0.005 0.021 0.5
Loa Loa (eye worm) hypoxia-induced factor 1 0.0158 0.2132 0.2772
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0161 0.2184 0.9525
Brugia malayi Thioredoxin reductase 0.005 0.021 0.0294
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0235 0.0016
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0222 0.0967
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0529 0.8728 1
Plasmodium falciparum glutathione reductase 0.005 0.021 0.5
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.044 0.7146 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0167 0.2293 1
Mycobacterium ulcerans putative regulatory protein 0.0038 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0167 0.2293 0.3004
Brugia malayi hypoxia-induced factor 1 0.0158 0.2132 0.2984
Loa Loa (eye worm) hypothetical protein 0.0171 0.2368 0.3111
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0167 0.2293 0.2435
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0167 0.2293 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0222 0.0967
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0167 0.2293 0.2435
Brugia malayi Pre-SET motif family protein 0.044 0.7146 1
Brugia malayi SET domain containing protein 0.0368 0.5874 0.822
Onchocerca volvulus 0.0529 0.8728 0.8728
Loa Loa (eye worm) hypothetical protein 0.035 0.5555 0.7707

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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