Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carbonic anhydrase II | 0.1489 | 1 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1422 | 0.9222 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1489 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1422 | 0.9222 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1489 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0656 | 0.0336 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1489 | 1 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1106 | 0.5552 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1489 | 1 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0944 | 0.367 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1106 | 0.5552 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.1106 | 0.5552 | 0.5397 |
Leishmania major | carbonic anhydrase-like protein | 0.1489 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1489 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1422 | 0.9222 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0656 | 0.0336 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1489 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1489 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1489 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1489 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.