Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | myotubularin protein 13 | 0.0031 | 0.0116 | 1 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0223 | 0.388 | 0.971 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.3866 | 0.9673 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.3384 | 0.8468 |
Echinococcus multilocularis | myotubularin protein 13 | 0.0031 | 0.0116 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0116 | 0.029 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0535 | 1 | 0.5 |
Brugia malayi | C1-like domain containing protein | 0.0223 | 0.388 | 1 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0223 | 0.388 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.3996 | 1 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0199 | 0.3399 | 0.8504 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.0535 | 1 | 0.5 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0535 | 1 | 0.5 |
Onchocerca volvulus | 0.0229 | 0.3996 | 1 | |
Schistosoma mansoni | vav2 | 0.0031 | 0.0116 | 0.0299 |
Schistosoma mansoni | protein kinase C mu | 0.0223 | 0.388 | 1 |
Onchocerca volvulus | 0.0222 | 0.3866 | 0.7864 | |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.3384 | 0.8468 |
Brugia malayi | Pleckstrin Homology Domain | 0.0031 | 0.0116 | 0.0299 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.