Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0963 | 0.3389 | 0.5922 |
Schistosoma mansoni | hypothetical protein | 0.0383 | 0.1088 | 0.1088 |
Onchocerca volvulus | Putative sulfate transporter | 0.0202 | 0.0372 | 0.3619 |
Toxoplasma gondii | hypothetical protein | 0.0383 | 0.1088 | 0.5 |
Onchocerca volvulus | 0.0368 | 0.1029 | 1 | |
Echinococcus multilocularis | carbonic anhydrase | 0.0383 | 0.1088 | 0.482 |
Mycobacterium ulcerans | carbonic anhydrase | 0.2128 | 0.8009 | 0.8009 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0383 | 0.1088 | 0.1088 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0297 | 0.0751 | 0.2084 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0677 | 0.2257 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.06 | 0.1665 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0677 | 0.2257 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0383 | 0.1088 | 0.482 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.1347 | 0.4911 | 0.4911 |
Loa Loa (eye worm) | hypothetical protein | 0.0383 | 0.1088 | 0.3021 |
Echinococcus granulosus | carbonic anhydrase | 0.0383 | 0.1088 | 0.482 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0111 | 0.001 | 0.001 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0677 | 0.2257 | 0.6267 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0383 | 0.1088 | 0.482 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0677 | 0.2257 | 0.2257 |
Echinococcus multilocularis | aminopeptidase N | 0.0368 | 0.1029 | 0.4559 |
Loa Loa (eye worm) | hypothetical protein | 0.0383 | 0.1088 | 0.3021 |
Echinococcus granulosus | carbonic anhydrase | 0.0383 | 0.1088 | 0.482 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0383 | 0.1088 | 0.482 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.263 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0677 | 0.2257 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0383 | 0.1088 | 0.3021 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0383 | 0.1088 | 0.1088 |
Echinococcus granulosus | carbonic anhydrase | 0.0383 | 0.1088 | 0.482 |
Echinococcus granulosus | carbonic anhydrase II | 0.0677 | 0.2257 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0383 | 0.1088 | 0.482 |
Schistosoma mansoni | carbonic anhydrase | 0.263 | 1 | 1 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0245 | 0.0542 | 0.0542 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0677 | 0.2257 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0383 | 0.1088 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0383 | 0.1088 | 0.482 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2128 | 0.8009 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0383 | 0.1088 | 0.1088 |
Echinococcus granulosus | aminopeptidase N | 0.0368 | 0.1029 | 0.4559 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0383 | 0.1088 | 0.482 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0677 | 0.2257 | 0.6267 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0677 | 0.2257 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.0368 | 0.1029 | 0.4559 |
Loa Loa (eye worm) | hypothetical protein | 0.1016 | 0.3601 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.0878 | 0.2438 |
Leishmania major | carbonic anhydrase-like protein | 0.0677 | 0.2257 | 0.2257 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0677 | 0.2257 | 0.2257 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.1398 | 0.5116 | 0.946 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0383 | 0.1088 | 0.1088 |
Echinococcus multilocularis | carbonic anhydrase | 0.0383 | 0.1088 | 0.482 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0677 | 0.2257 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.263 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2128 | 0.8009 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.1465 | 0.538 | 1 |
Onchocerca volvulus | 0.0202 | 0.0372 | 0.3619 | |
Leishmania major | carbonic anhydrase family protein, putative | 0.263 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.